Literature DB >> 1833209

Involvement of hypothalamic serotonin in activation of the sympathoadrenomedullary system and hypothalamo-pituitary-adrenocortical axis in male Wistar rats.

S M Korte1, S Van Duin, G A Bouws, J M Koolhaas, B Bohus.   

Abstract

Infusion of the 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) (2.5-20 micrograms in 1 microliter during 15 min), into the paraventricular nucleus of the hypothalamus (PVN) in the rat dose dependently increased plasma adrenaline and corticosterone concentrations, without affecting plasma noradrenaline concentrations. The highest dose also increased plasma glucose levels significantly. The results suggest that both the sympathoadrenomedullary system and the hypothalamo-pituitary-adrenocortical axis are activated after stimulation of 5-HT1A receptors in the PVN.

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Year:  1991        PMID： 1833209     DOI： 10.1016/0014-2999(91)90527-w

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  7 in total

Review 1.  Molecular mechanisms of actions of interleukin-6 on the brain, with special reference to serotonin and the hypothalamo-pituitary-adrenocortical axis.

Authors:  N Barkhudaryan; A J Dunn
Journal:  Neurochem Res       Date:  1999-09       Impact factor: 3.996

2.  Effect of stress on the behavior and 5-HT system in Sprague-Dawley and Wistar Kyoto rat strains.

Authors:  W P Paré; S M Tejani-Butt
Journal:  Integr Physiol Behav Sci       Date:  1996 Apr-Jun

3.  The selective serotonin reuptake inhibitor sertraline enhances counterregulatory responses to hypoglycemia.

Authors:  Nicole M Sanders; Charles W Wilkinson; Gerald J Taborsky; Salwa Al-Noori; Wendi Daumen; Aryana Zavosh; Dianne P Figlewicz
Journal:  Am J Physiol Endocrinol Metab       Date:  2008-03-11       Impact factor: 4.310

4.  The Effects of Tryptophan Enhancement and Depletion on Plasma Catecholamine Levels in Healthy Individuals.

Authors:  Stephen H Boyle; Beverly H Brummett; Cynthia M Kuhn; John C Barefoot; Ilene C Siegler; Redford B Williams; Anastasia Georgiades
Journal:  Psychosom Med       Date:  2019-01       Impact factor: 4.312

Review 5.  Living without insulin: the role of leptin signaling in the hypothalamus.

Authors:  Teppei Fujikawa; Roberto Coppari
Journal:  Front Neurosci       Date:  2015-03-27       Impact factor: 4.677

6.  Effect of serotonin depletion on the neuronal, endocrine and behavioural responses to corticotropin-releasing factor in the rat.

Authors:  Yasin Temel; Adel Helmy; Scarlett Pinnock; Joe Herbert
Journal:  Neurosci Lett       Date:  2003-02-27       Impact factor: 3.046

7.  Decrease in Salivary Serotonin in Response to Probiotic Supplementation With Saccharomyces boulardii in Healthy Volunteers Under Psychological Stress: Secondary Analysis of a Randomized, Double-Blind, Placebo-Controlled Trial.

Authors:  Michał Seweryn Karbownik; Joanna Kręczyńska; Anna Wiktorowska-Owczarek; Paulina Kwarta; Magdalena Cybula; Nebojša Stilinović; Tadeusz Pietras; Edward Kowalczyk
Journal:  Front Endocrinol (Lausanne)       Date:  2022-01-06       Impact factor: 5.555
  7 in total

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