Literature DB >> 8808057

Rearrangement/hypermutation/gene conversion: when, where and why?

J C Weill1, C A Reynaud.   

Abstract

Diversification strategies for immunoglobulins vary widely in different species. Here, Jean-Claude Weill and Claude-Agnès Reynaud argue that V(D)J recombination arose as a means for achieving allelic exclusion rather than diversity, and postulate that the choice of a diversification strategy is selected along with a specific site of B-cell differentiation. They propose that somatic mutation and gene conversion represent analogous molecular strategies occurring in specific chromatin accessibility contexts.

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Year:  1996        PMID： 8808057     DOI： 10.1016/0167-5699(96)80586-x

Source DB:  PubMed          Journal:  Immunol Today        ISSN： 0167-5699


  17 in total

Review 1.  Evolution and the molecular basis of somatic hypermutation of antigen receptor genes.

Authors:  M Diaz; M F Flajnik; N Klinman
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2001-01-29       Impact factor: 6.237

2.  The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially.

Authors:  C Rada; C Milstein
Journal:  EMBO J       Date:  2001-08-15       Impact factor: 11.598

Review 3.  Somatic immunoglobulin hypermutation.

Authors:  Marilyn Diaz; Paolo Casali
Journal:  Curr Opin Immunol       Date:  2002-04       Impact factor: 7.486

4.  B cell variable genes have evolved their codon usage to focus the targeted patterns of somatic mutation on the complementarity determining regions.

Authors:  Jasmine Saini; Uri Hershberg
Journal:  Mol Immunol       Date:  2015-02-06       Impact factor: 4.407

5.  Cells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers.

Authors:  B Goyenechea; N Klix; J Yélamos; G T Williams; A Riddell; M S Neuberger; C Milstein
Journal:  EMBO J       Date:  1997-07-01       Impact factor: 11.598

6.  Acquisition of host-derived CD40L by HIV-1 in vivo and its functional consequences in the B-cell compartment.

Authors:  Michaël Imbeault; Michel Ouellet; Katia Giguère; Jonathan Bertin; Dave Bélanger; Geneviève Martin; Michel J Tremblay
Journal:  J Virol       Date:  2010-12-22       Impact factor: 5.103

7.  Gene conversion of major histocompatibility complex genes in the mouse spermatogenesis is a premeiotic event.

Authors:  K Högstrand; J Böhme
Journal:  Mol Biol Cell       Date:  1997-12       Impact factor: 4.138

8.  Defining the complementarities between antibodies and haptens to refine our understanding and aid the prediction of a successful binding interaction.

Authors:  Mohammed M Al Qaraghuli; Soumya Palliyil; Gillian Broadbent; David C Cullen; Keith A Charlton; Andrew J Porter
Journal:  BMC Biotechnol       Date:  2015-10-24       Impact factor: 2.563

9.  Patterns of receptor revision in the immunoglobulin heavy chains of a teleost fish.

Authors:  Miles D Lange; Geoffrey C Waldbieser; Craig J Lobb
Journal:  J Immunol       Date:  2009-05-01       Impact factor: 5.422

Review 10.  Class-switch recombination: after the dawn of AID.

Authors:  Amy L Kenter
Journal:  Curr Opin Immunol       Date:  2003-04       Impact factor: 7.486
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