Literature DB >> 8807860

Achieving natural product synthesis and diversity via catalytic networking ex vivo.

C A Roessner1, A I Scott.   

Abstract

Recent studies on ex vivo synthesis of natural products reveal that even complex multistep pathways can be successfully reconstructed. Genetic engineering of such reconstituted pathways has already been used to generate 'unnatural' natural products related to the original compound. In the future, it may be possible to use these approaches to make natural products that are currently inaccessible to conventional synthesis.

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Year:  1996        PMID： 8807860     DOI： 10.1016/s1074-5521(96)90114-3

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  11 in total

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2.  Enzymatic total synthesis of rabelomycin, an angucycline group antibiotic.

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Review 3.  Delineation of gilvocarcin, jadomycin, and landomycin pathways through combinatorial biosynthetic enzymology.

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4.  Enzymatic total synthesis of defucogilvocarcin M and its implications for gilvocarcin biosynthesis.

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5.  In vitro biosynthesis of unnatural enterocin and wailupemycin polyketides.

Authors:  John A Kalaitzis; Qian Cheng; Paul M Thomas; Neil L Kelleher; Bradley S Moore
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6.  In vitro precursor-directed synthesis of polyketide analogues with coenzyme a regeneration for the development of antiangiogenic agents.

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7.  Enzyme alchemy: cell-free synthetic biochemistry for natural products.

Authors:  Simon J Moore
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Review 8.  Natural products for cancer chemotherapy.

Authors:  Arnold L Demain; Preeti Vaishnav
Journal:  Microb Biotechnol       Date:  2010-11-18       Impact factor: 5.813

9.  Statistical experimental design guided optimization of a one-pot biphasic multienzyme total synthesis of amorpha-4,11-diene.

Authors:  Xixian Chen; Congqiang Zhang; Ruiyang Zou; Kang Zhou; Gregory Stephanopoulos; Heng Phon Too
Journal:  PLoS One       Date:  2013-11-20       Impact factor: 3.240

10.  Natural products chemistry: The emerging trends and prospective goals.

Authors:  Riaz A Khan
Journal:  Saudi Pharm J       Date:  2018-02-07       Impact factor: 4.330
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