Literature DB >> 8807859

Exploiting the potential of antisense: beyond phosphorothioate oligodeoxynucleotides.

C A Stein1.   

Abstract

Phosphorothioate oligodeoxynucleotides, designed as nuclease-resistant antisense agents, appear to have a number of surprising biological effects that are unrelated to their intended antisense activity. These effects may be useful in themselves, but must be understood for the full potential of antisense technology to be realized.

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Year:  1996        PMID： 8807859     DOI： 10.1016/s1074-5521(96)90113-1

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  12 in total

1.  Construction and selection of bead-bound combinatorial oligonucleoside phosphorothioate and phosphorodithioate aptamer libraries designed for rapid PCR-based sequencing.

Authors:  Xianbin Yang; Suzanne E Bassett; Xin Li; Bruce A Luxon; Norbert K Herzog; Robert E Shope; Judy Aronson; Tarl W Prow; James F Leary; Romy Kirby; Andrew D Ellington; David G Gorenstein
Journal:  Nucleic Acids Res       Date:  2002-12-01       Impact factor: 16.971

Review 2.  Twenty years hunting for sulfur in DNA.

Authors:  Shi Chen; Lianrong Wang; Zixin Deng
Journal:  Protein Cell       Date:  2010-02-07       Impact factor: 14.870

3.  Conformational studies of antisense DNA by PFG NMR.

Authors:  X Yang; Y S Sanghvi; X Gao
Journal:  J Biomol NMR       Date:  1997-12       Impact factor: 2.835

4.  Inhibition of gene expression by anti-sense C-5 propyne oligonucleotides detected by a reporter enzyme.

Authors:  Y Hamel; J Lacoste; C Frayssinet; A Sarasin; T Garestier; J C François; C Hélène
Journal:  Biochem J       Date:  1999-05-01       Impact factor: 3.857

5.  2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity.

Authors:  Sherry Y Wu; Xianbin Yang; Kshipra M Gharpure; Hiroto Hatakeyama; Martin Egli; Michael H McGuire; Archana S Nagaraja; Takahito M Miyake; Rajesha Rupaimoole; Chad V Pecot; Morgan Taylor; Sunila Pradeep; Malgorzata Sierant; Cristian Rodriguez-Aguayo; Hyun J Choi; Rebecca A Previs; Guillermo N Armaiz-Pena; Li Huang; Carlos Martinez; Tom Hassell; Cristina Ivan; Vasudha Sehgal; Richa Singhania; Hee-Dong Han; Chang Su; Ji Hoon Kim; Heather J Dalton; Chandra Kovvali; Khandan Keyomarsi; Nigel A J McMillan; Willem W Overwijk; Jinsong Liu; Ju-Seog Lee; Keith A Baggerly; Gabriel Lopez-Berestein; Prahlad T Ram; Barbara Nawrot; Anil K Sood
Journal:  Nat Commun       Date:  2014-03-12       Impact factor: 14.919

6.  Increased miR-132-3p expression is associated with chronic neuropathic pain.

Authors:  M Leinders; N Üçeyler; R A Pritchard; C Sommer; L S Sorkin
Journal:  Exp Neurol       Date:  2016-06-24       Impact factor: 5.330

7.  [Antisense oligonucleotides for therapy of cystic fibrosis. Inhibition of sodium absorption mediated by ENaC in nasal epithelial cells].

Authors:  K Sobczak; N Bangel-Ruland; J Semmler; H Lindemann; R Heermann; W-M Weber
Journal:  HNO       Date:  2009-11       Impact factor: 1.284

Review 8.  Diagnostic and Therapeutic Value of Aptamers in Envenomation Cases.

Authors:  Steven Ascoët; Michel De Waard
Journal:  Int J Mol Sci       Date:  2020-05-18       Impact factor: 5.923

9.  In vitro analysis of phosphorothioate modification of DNA reveals substrate recognition by a multiprotein complex.

Authors:  Bo Cao; Xiaoqing Zheng; Qiuxiang Cheng; Fen Yao; Tao Zheng; I Ramesh Babu; Huchen Zhou; Peter Dedon; Delin You
Journal:  Sci Rep       Date:  2015-07-27       Impact factor: 4.379

10.  Comparison of the 'chemical' and 'structural' approaches to the optimization of the thrombin-binding aptamer.

Authors:  Olga Tatarinova; Vladimir Tsvetkov; Dmitry Basmanov; Nikolay Barinov; Igor Smirnov; Edward Timofeev; Dmitry Kaluzhny; Andrey Chuvilin; Dmitry Klinov; Anna Varizhuk; Galina Pozmogova
Journal:  PLoS One       Date:  2014-02-20       Impact factor: 3.240
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