Literature DB >> 8807824

Bacterial resistance to vancomycin: five genes and one missing hydrogen bond tell the story.

C T Walsh1, S L Fisher, I S Park, M Prahalad, Z Wu.   

Abstract

A plasmid-borne transposon encodes enzymes and regulator proteins that confer resistance of enterococcal bacteria to the antibiotic vancomycin. Purification and characterization of individual proteins encoded by this operon has helped to elucidate the molecular basis of vancomycin resistance. This new understanding provides opportunities for intervention to reverse resistance.

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Year:  1996        PMID： 8807824     DOI： 10.1016/s1074-5521(96)90079-4

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  64 in total

1.  The molecular basis of vancomycin resistance in clinically relevant Enterococci: crystal structure of D-alanyl-D-lactate ligase (VanA).

Authors:  D I Roper; T Huyton; A Vagin; G Dodson
Journal:  Proc Natl Acad Sci U S A       Date:  2000-08-01       Impact factor: 11.205

2.  Assembling the glycopeptide antibiotic scaffold: The biosynthesis of A47934 from Streptomyces toyocaensis NRRL15009.

Authors:  Jeff Pootoolal; Michael G Thomas; C Gary Marshall; John M Neu; Brian K Hubbard; Christopher T Walsh; Gerard D Wright
Journal:  Proc Natl Acad Sci U S A       Date:  2002-06-11       Impact factor: 11.205

Review 3.  Roles of tRNA in cell wall biosynthesis.

Authors:  Kiley Dare; Michael Ibba
Journal:  Wiley Interdiscip Rev RNA       Date:  2012-01-19       Impact factor: 9.957

4.  Catalysis at the intersection of biology, chemistry, and medicine.

Authors:  Christopher T Walsh
Journal:  J Biol Chem       Date:  2010-07-01       Impact factor: 5.157

5.  A stepwise dechlorination/cross-coupling strategy to diversify the vancomycin 'in-chloride'.

Authors:  Tyler J Wadzinski; Katherine D Gea; Scott J Miller
Journal:  Bioorg Med Chem Lett       Date:  2015-12-11       Impact factor: 2.823

6.  The Mechanism of Action of Lysobactin.

Authors:  Wonsik Lee; Kaitlin Schaefer; Yuan Qiao; Veerasak Srisuknimit; Heinrich Steinmetz; Rolf Müller; Daniel Kahne; Suzanne Walker
Journal:  J Am Chem Soc       Date:  2015-12-24       Impact factor: 15.419

Review 7.  Vancomycin resistance in enterococci due to synthesis of precursors terminating in D-alanyl-D-serine.

Authors:  Peter E Reynolds; Patrice Courvalin
Journal:  Antimicrob Agents Chemother       Date:  2005-01       Impact factor: 5.191

8.  Telavancin, a multifunctional lipoglycopeptide, disrupts both cell wall synthesis and cell membrane integrity in methicillin-resistant Staphylococcus aureus.

Authors:  Deborah L Higgins; Ray Chang; Dmitri V Debabov; Joey Leung; Terry Wu; Kevin M Krause; Erik Sandvik; Jeffrey M Hubbard; Koné Kaniga; Donald E Schmidt; Qiufeng Gao; Robert T Cass; Dane E Karr; Bret M Benton; Patrick P Humphrey
Journal:  Antimicrob Agents Chemother       Date:  2005-03       Impact factor: 5.191

Review 9.  Total Syntheses of Vancomycin-Related Glycopeptide Antibiotics and Key Analogues.

Authors:  Akinori Okano; Nicholas A Isley; Dale L Boger
Journal:  Chem Rev       Date:  2017-04-24       Impact factor: 60.622

10.  Hexapeptide derivatives of glycopeptide antibiotics: tools for mechanism of action studies.

Authors:  Norris E Allen; Deborah L LeTourneau; Joe N Hobbs; Richard C Thompson
Journal:  Antimicrob Agents Chemother       Date:  2002-08       Impact factor: 5.191
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