Literature DB >> 8807812

Ribonucleotide reductases: radical enzymes with suicidal tendencies.

J Stubbe1, W A van der Donk.   

Abstract

Ribonucleotide reductases catalyze a key step in DNA biosynthesis, using a diverse array of unprecedented metallo-cofactors to generate a transient protein radical that initiates nucleotide reduction. The new understanding of the chemistry and biochemistry of the system has allowed rational design of inhibitors of this process, which function as antitumor and antiviral agents.

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Year:  1995        PMID： 8807812     DOI： 10.1016/1074-5521(95)90084-5

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  41 in total

1.  C3'-Deoxygenation of Paromamine Catalyzed by a Radical S-Adenosylmethionine Enzyme: Characterization of the Enzyme AprD4 and Its Reductase Partner AprD3.

Authors:  Hak Joong Kim; Jake LeVieux; Yu-Cheng Yeh; Hung-Wen Liu
Journal:  Angew Chem Int Ed Engl       Date:  2016-02-16       Impact factor: 15.336

2.  S434F in NrdE generates the thermosensitive phenotype of corynebacterium ammoniagenes CH31 and enhances thermolability by increasing the surface hydrophobicity of the NrdE(Ts) protein.

Authors:  Hesham M Elhariry; Jochen Meens; Matthias Stehr; Georg Auling
Journal:  Appl Environ Microbiol       Date:  2005-09       Impact factor: 4.792

3.  Dehydration of ribonucleotides catalyzed by ribonucleotide reductase: the role of the enzyme.

Authors:  Nuno M F S A Cerqueira; Pedro Alexandrino Fernandes; Leif A Eriksson; Maria João Ramos
Journal:  Biophys J       Date:  2005-12-16       Impact factor: 4.033

4.  Structure, redox, pKa, spin. A golden tetrad for understanding metalloenzyme energetics and reaction pathways.

Authors:  Louis Noodleman; Wen-Ge Han
Journal:  J Biol Inorg Chem       Date:  2006-07-08       Impact factor: 3.358

5.  Enhanced subunit interactions with gemcitabine-5'-diphosphate inhibit ribonucleotide reductases.

Authors:  Jun Wang; Gregory J S Lohman; JoAnne Stubbe
Journal:  Proc Natl Acad Sci U S A       Date:  2007-08-28       Impact factor: 11.205

6.  Mechanistic Enzymology of the Radical SAM Enzyme DesII.

Authors:  Mark W Ruszczycky; Hung-Wen Liu
Journal:  Isr J Chem       Date:  2015-02-20       Impact factor: 3.333

7.  Artificial Diiron Enzymes with a De Novo Designed Four-Helix Bundle Structure.

Authors:  Marco Chino; Ornella Maglio; Flavia Nastri; Vincenzo Pavone; William F DeGrado; Angela Lombardi
Journal:  Eur J Inorg Chem       Date:  2015-07-06       Impact factor: 2.524

8.  Inactivation of Lactobacillus leichmannii ribonucleotide reductase by 2',2'-difluoro-2'-deoxycytidine 5'-triphosphate: adenosylcobalamin destruction and formation of a nucleotide-based radical.

Authors:  Gregory J S Lohman; Gary J Gerfen; Joanne Stubbe
Journal:  Biochemistry       Date:  2010-02-23       Impact factor: 3.162

Review 9.  Redox Signaling by Reactive Electrophiles and Oxidants.

Authors:  Saba Parvez; Marcus J C Long; Jesse R Poganik; Yimon Aye
Journal:  Chem Rev       Date:  2018-08-27       Impact factor: 60.622

10.  Structures of eukaryotic ribonucleotide reductase I define gemcitabine diphosphate binding and subunit assembly.

Authors:  Hai Xu; Catherine Faber; Tomoaki Uchiki; Joseph Racca; Chris Dealwis
Journal:  Proc Natl Acad Sci U S A       Date:  2006-03-06       Impact factor: 11.205
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