Literature DB >> 8807074

Improved survival and antagonistic effect of sodium fusidate on tumor necrosis factor alpha in a neonatal mouse model of endotoxin shock.

F Genovese1, G Mancuso, M Cuzzola, V Cusumano, F Nicoletti, K Bendtzen, G Teti.   

Abstract

Unlike the antibiotics erythromycin and penicillin G, sodium fusidate (fusidin) pretreatment (80 mg/kg of body weight) increased the survival rate of neonatal BALB/c mice challenged with Salmonella enteritidis lipopolysaccharide. Fusidin also significantly reduced the plasma tumor necrosis factor alpha levels. Hence, fusidin may prove useful in the management of bacterial sepsis in humans.

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Year:  1996        PMID： 8807074      PMCID： PMC163407     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  27 in total

1.  Fusidic acid: a new antibiotic.

Authors:  W O GODTFREDSEN; S JAHNSEN; H LORCK; K ROHOLT; L TYBRING
Journal:  Nature       Date:  1962-03-10       Impact factor: 49.962

2.  Sodium fusidate and increased remission rate of insulin-dependent diabetes mellitus.

Authors:  F Nicoletti; P L Meroni; M Lunetta; R Vigo; T Palermo; D Papalia; W Barcellini; M Di Mauro; M Caruso-Nicoletti; L Mughini
Journal:  Lancet       Date:  1991-05-25       Impact factor: 79.321

3.  Pathogenesis of colonization and infection in a neonatal surgical unit.

Authors:  E M Leonard; H K van Saene; P Shears; J Walker; P K Tam
Journal:  Crit Care Med       Date:  1990-03       Impact factor: 7.598

Review 4.  The pharmacokinetics of fusidic acid.

Authors:  D S Reeves
Journal:  J Antimicrob Chemother       Date:  1987-10       Impact factor: 5.790

5.  Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia.

Authors:  K J Tracey; Y Fong; D G Hesse; K R Manogue; A T Lee; G C Kuo; S F Lowry; A Cerami
Journal:  Nature       Date:  1987 Dec 17-23       Impact factor: 49.962

6.  The role of IFN-gamma in the pathology of experimental endotoxemia.

Authors:  F P Heinzel
Journal:  J Immunol       Date:  1990-11-01       Impact factor: 5.422

7.  Fusidic acid, an immunosuppressive drug with functions similar to cyclosporin A.

Authors:  K Bendtzen; M Diamant; V Faber
Journal:  Cytokine       Date:  1990-11       Impact factor: 3.861

8.  Effects of sodium fusidate in animal models of insulin-dependent diabetes mellitus and septic shock.

Authors:  F Nicoletti; P Zaccone; R Di Marco; G Magro; S Grasso; S Morrone; A Santoni; G Tempera; P L Meroni; K Bendtzen
Journal:  Immunology       Date:  1995-08       Impact factor: 7.397

9.  Mortality, temporal substrate and insulin responses to endotoxic shock in zero, ten and twenty-eight day old rats.

Authors:  W P Zeller; M Goto; L Witek-Janusek; R M Hurley
Journal:  Surg Gynecol Obstet       Date:  1991-11

Review 10.  Interleukin-1 and interleukin-1 antagonism.

Authors:  C A Dinarello
Journal:  Blood       Date:  1991-04-15       Impact factor: 22.113
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  4 in total

Review 1.  Interference of antibacterial agents with phagocyte functions: immunomodulation or "immuno-fairy tales"?

Authors:  M T Labro
Journal:  Clin Microbiol Rev       Date:  2000-10       Impact factor: 26.132

Review 2.  Natural pathogens of laboratory mice, rats, and rabbits and their effects on research.

Authors:  D G Baker
Journal:  Clin Microbiol Rev       Date:  1998-04       Impact factor: 26.132

3.  Endotoxin-induced lethality in neonatal mice is counteracted by interleukin-10 (IL-10) and exacerbated by anti-IL-10.

Authors:  F Nicoletti; G Mancuso; F A Ciliberti; C Beninati; M Carbone; S Franco; V Cusumano
Journal:  Clin Diagn Lab Immunol       Date:  1997-09

4.  Cardiac function and circulating cytokines after endotoxin exposure in neonatal mice.

Authors:  Rupak Mukherjee; Tim C McQuinn; Melissa A Dugan; J Philip Saul; Francis G Spinale
Journal:  Pediatr Res       Date:  2010-11       Impact factor: 3.756
  4 in total

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