Literature DB >> 8805530

A complex profile of protein elongation: translating chemical energy into molecular movement.

K Abel1, F Jurnak.   

Abstract

The recently solved structures of the protein elongation factor complexes, EF-Tu-GDPNP-phenylalanyl-tRNA and EF-T-Ts, complete the atomic profile of four EF-Tu conformational states. As a set, the three-dimensional structures suggest an atomic model for movement during protein elongation and, by molecular mimicry with EF-G, translocation as well.

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Year:  1996        PMID: 8805530     DOI: 10.1016/S0969-2126(96)00027-5

Source DB:  PubMed          Journal:  Structure        ISSN: 0969-2126            Impact factor:   5.006


  13 in total

Review 1.  Macromolecular mimicry.

Authors:  P Nissen; M Kjeldgaard; J Nyborg
Journal:  EMBO J       Date:  2000-02-15       Impact factor: 11.598

2.  Three-dimensional cryo-electron microscopy localization of EF2 in the Saccharomyces cerevisiae 80S ribosome at 17.5 A resolution.

Authors:  M G Gomez-Lorenzo; C M Spahn; R K Agrawal; R A Grassucci; P Penczek; K Chakraburtty; J P Ballesta; J L Lavandera; J F Garcia-Bustos; J Frank
Journal:  EMBO J       Date:  2000-06-01       Impact factor: 11.598

3.  Elongation factor G stabilizes the hybrid-state conformation of the 70S ribosome.

Authors:  P Clint Spiegel; Dmitri N Ermolenko; Harry F Noller
Journal:  RNA       Date:  2007-07-13       Impact factor: 4.942

4.  rRNA suppressor of a eukaryotic translation initiation factor 5B/initiation factor 2 mutant reveals a binding site for translational GTPases on the small ribosomal subunit.

Authors:  Byung-Sik Shin; Joo-Ran Kim; Michael G Acker; Kathryn N Maher; Jon R Lorsch; Thomas E Dever
Journal:  Mol Cell Biol       Date:  2008-11-24       Impact factor: 4.272

5.  Form follows function: structure of an elongation factor G-ribosome complex.

Authors:  M V Rodnina; W Wintermeyer
Journal:  Proc Natl Acad Sci U S A       Date:  1998-06-23       Impact factor: 11.205

6.  Specific peptide-activated proteolytic cleavage of Escherichia coli elongation factor Tu.

Authors:  T Georgiou; Y N Yu; S Ekunwe; M J Buttner; A Zuurmond; B Kraal; C Kleanthous; L Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1998-03-17       Impact factor: 11.205

Review 7.  Translational regulation by modifications of the elongation factor Tu.

Authors:  B Kraal; C Lippmann; C Kleanthous
Journal:  Folia Microbiol (Praha)       Date:  1999       Impact factor: 2.099

8.  An evolutionarily conserved U5 snRNP-specific protein is a GTP-binding factor closely related to the ribosomal translocase EF-2.

Authors:  P Fabrizio; B Laggerbauer; J Lauber; W S Lane; R Lührmann
Journal:  EMBO J       Date:  1997-07-01       Impact factor: 11.598

9.  Interaction of Mycobacterium tuberculosis elongation factor Tu with GTP is regulated by phosphorylation.

Authors:  Andaleeb Sajid; Gunjan Arora; Meetu Gupta; Anshika Singhal; Kausik Chakraborty; Vinay Kumar Nandicoori; Yogendra Singh
Journal:  J Bacteriol       Date:  2011-07-29       Impact factor: 3.490

10.  Archaeal elongation factor 1alpha from Sulfolobus solfataricus interacts with the eubacterial antibiotic GE2270A.

Authors:  Mariorosario Masullo; Piergiuseppe Cantiello; Paolo Arcari
Journal:  Extremophiles       Date:  2004-07-30       Impact factor: 2.395

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