Literature DB >> 880236

Permeability of the liver cell membrane to quinolinate.

K R Elliott, C I Pogson, S A Smith.   

Abstract

Quinolinate was taken up by both rat and guinea-pig liver cells. Equilibrium was reached after approx. 20 min with rat cells, but guinea-pig cells had not achieved a steady state after 60 min. There was no evidence to suggest that quinolinate is rapidly metabolized by either species. The concentrations of quinolinate attained in rat and guinea-pig cells after short periods of incubation with 0.5 mM-quinolinate did not inhibit gluconeogenesis. These results raise further doubts as to the mechanism of quinolinate action in liver.

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Year:  1977        PMID： 880236      PMCID： PMC1164787          DOI： 10.1042/bj1640283

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  17 in total

1.  THE ENZYMATIC CONVERSION OF QUINOLINATE TO NICOTINIC ACID MONONUCLEOTIDE IN MAMMALIAN LIVER.

Authors:  R K GHOLSON; I UEDA; N OGASAWARA; L M HENDERSON
Journal:  J Biol Chem       Date:  1964-04       Impact factor: 5.157

Review 2.  Phosphoenolpyruvate carboxykinase. I. Its role in gluconeogenesis.

Authors:  R W Hanson; A J Garber
Journal:  Am J Clin Nutr       Date:  1972-10       Impact factor: 7.045

3.  Metabolism of pyridinium precursors of pyridine nucleotides in perfused rat liver.

Authors:  Y Hagino; S J Lan; C Y Ng; L M Henderson
Journal:  J Biol Chem       Date:  1968-10-10       Impact factor: 5.157

4.  Studies on the biosynthesis of nicotinamide adenine dinucleotide. 3. Comparative in vivo studies on nicotinic acid, nicotinamide, and quinolinic acid as precursors of nicotinamide adenine dinucleotide.

Authors:  H Ijichi; A Ichiyama; O Hayaishi
Journal:  J Biol Chem       Date:  1966-08-25       Impact factor: 5.157

5.  Hypoglycemic action of tryptophan.

Authors:  H G McDaniel; B R Boshell; W J Reddy
Journal:  Diabetes       Date:  1973-09       Impact factor: 9.461

6.  Serum tryptophan level after carbohydrate ingestion: selective decline in non-albumin-bound tryptophan coincident with reduction in serum free fatty acids.

Authors:  D Lipsett; B K Madras; R J Wurtman; H N Munro
Journal:  Life Sci II       Date:  1973-01-22

7.  The effect of quinolinic acid on the content and distribution of hepatic metabolites.

Authors:  O S Spydervold; N Zaheer-Baquer; P McLean; A L Greenbaum
Journal:  Arch Biochem Biophys       Date:  1974-10       Impact factor: 4.013

8.  Removal of fatty acids from serum albumin by charcoal treatment.

Authors:  R F Chen
Journal:  J Biol Chem       Date:  1967-01-25       Impact factor: 5.157

9.  The activity of phosphoenolpyruvate carboxykinase in rat tissues. Assay techniques and effects of dietary and hormonal changes.

Authors:  C I Pogson; S A Smith
Journal:  Biochem J       Date:  1975-11       Impact factor: 3.857

10.  Interaction of anions and divalent metal ions with phosphoenolpyruvate carboxykinase.

Authors:  L A Bentle; H A Lardy
Journal:  J Biol Chem       Date:  1976-05-25       Impact factor: 5.157
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  7 in total

1.  The kinetics of transport of lactate and pyruvate into rat hepatocytes. Evidence for the presence of a specific carrier similar to that in erythrocytes.

Authors:  G L Edlund; A P Halestrap
Journal:  Biochem J       Date:  1988-01-01       Impact factor: 3.857

2.  Differential effects of tryptophan on glucose synthesis in rats and guinea pigs.

Authors:  S A Smith; K R Elliott; C I Pogson
Journal:  Biochem J       Date:  1978-12-15       Impact factor: 3.857

3.  Effect of alloxan-diabetes on gluconeogenesis and ureogenesis in isolated rabbit liver cells.

Authors:  J Zaleski; J Bryła
Journal:  Biochem J       Date:  1978-11-15       Impact factor: 3.857

4.  Tryptophan and glucose metabolism in rat liver cells. The effects of DL-6-chlorotryptophan, 4-chloro-3-hydroxyanthranilate and pyrazinamide.

Authors:  J S Cook; C I Pogson
Journal:  Biochem J       Date:  1983-08-15       Impact factor: 3.857

5.  The rôle of mitochondrial pyruvate transport in the stimulation by glucagon and phenylephrine of gluconeogenesis from L-lactate in isolated rat hepatocytes.

Authors:  A P Thomas; A P Halestrap
Journal:  Biochem J       Date:  1981-09-15       Impact factor: 3.857

6.  Possible involvement of the enhanced tryptophan pyrrolase activity in the corticosterone- and starvation-induced increases in concentrations of nicotinamide-adenine dinucleotides (phosphates) in rat liver.

Authors:  A A Badawy
Journal:  Biochem J       Date:  1981-04-15       Impact factor: 3.857

7.  The metabolism of L-tryptophan by isolated rat liver cells. Quantification of the relative importance of, and the effect of nutritional status on, the individual pathways of tryptophan metabolism.

Authors:  S A Smith; F P Carr; C I Pogson
Journal:  Biochem J       Date:  1980-11-15       Impact factor: 3.857
  7 in total

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