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Literature DB >> 747654

Differential effects of tryptophan on glucose synthesis in rats and guinea pigs.

Abstract

1. Tryptophan inhibition of gluconeogenesis in isolated rat liver cells is characterized by a 20 min lag period before linear rates of glucose output are attained. 2. Half-maximal inhibition of gluconeogenesis in isolated rat hepatocytes is produced by approx. 0.1 mM-tryptophan. 3. Tryptophan inhibits gluconeogenesis from all substrates giving rise to oxaloacetate, but stimulates glycerol-fuelled glucose production. 4. Gluconeogenesis in guinea-pig hepatocytes is insensitive to tryptophan. 5. Changes in metabolite concentrations in rat liver cells are consistent with a locus of inhibition at the step catalysed by phosphoenolpyruvate carboxykinase. 6. Inhibition of gluconeogenesis persists in cells from rats pretreated with tryptophan in vivo. 7. Tryptophan has no effect on urea production from alanine, but decreases [1-14C]palmitate oxidation to 14CO2 and is associated with an increased [hydroxybutyrate]/[acetoacetate] ratio. 8. These results are discussed with reference to the control of gluconeogenesis in various species.

Entities: Chemical Species

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Year: 1978 PMID： 747654 PMCID： PMC1186305 DOI： 10.1042/bj1760817

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

55 in total

1. GLUCOCORTICOIDS AND TRANSAMINASE ACTIVITY. VII. STUDIES ON THE NATURE AND SPECIFICITY OF SUBSTRATE INDUCTION OF TYROSINE-ALPHA-KETOGLUTARATE TRANSAMINASE AND TRYPTOPHAN PYRROLASE.

Authors: F ROSEN; R J MILHOLLAND
Journal: J Biol Chem Date: 1963-11 Impact factor: 5.157

2. STUDIES ON THE BIOSYNTHESIS OF NICOTINAMIDE ADENINE DINUCLEOTIDE. II. A ROLE OF PICOLINIC CARBOXYLASE IN THE BIOSYNTHESIS OF NICOTINAMIDE ADENINE DINUCLEOTIDE FROM TRYPTOPHAN IN MAMMALS.

Authors: M IKEDA; H TSUJI; S NAKAMURA; A ICHIYAMA; Y NISHIZUKA; O HAYAISHI
Journal: J Biol Chem Date: 1965-03 Impact factor: 5.157

3. Renal gluconeogenesis. The effect of diet on the gluconeogenic capacity of rat-kidney-cortex slices.

Authors: H A KREBS; D A BENNETT; P DE GASQUET; P GASQUET; T GASCOYNE; T YOSHIDA
Journal: Biochem J Date: 1963-01 Impact factor: 3.857

4. Relation of cortisone and synthesis of ribonucleic acid to induced and developmental enzyme formation.

Authors: O GREENGARD; M A SMITH; G ACS
Journal: J Biol Chem Date: 1963-04 Impact factor: 5.157

5. A rapid and precise method for the determination of urea.

Authors: J K FAWCETT; J E SCOTT
Journal: J Clin Pathol Date: 1960-03 Impact factor: 3.411

6. The intermediary metabolism of tryptophan by cat and rat tissue preparations.

Authors: F T DE CASTRO; R R BROWN; J M PRICE
Journal: J Biol Chem Date: 1957-10 Impact factor: 5.157

7. The hypoglycemic and insulinase inhibitory action of L-tryptophan.

Authors: D DIENGOTT; I A MIRSKY; G PERISUTTI
Journal: Endocrinology Date: 1956-09 Impact factor: 4.736

8. The toxicity of essential amino acid mixtures with special reference to the protective effect of L-arginine.

Authors: P GULLINO; M WINITZ; S M BIRNBAUM; M C OTEY; J CORNFIELD; J P GREENSTEIN
Journal: Arch Biochem Biophys Date: 1955-09 Impact factor: 4.013

9. Lactate-stimulated ethanol oxidation in isolated rat hepatocytes.

Authors: K E Crow; N W Cornell; R L Veech
Journal: Biochem J Date: 1978-04-15 Impact factor: 3.857

10. The effects of starvation and experimental diabetes on phosphoenol-pyruvate carboxykinase in the guinea pig.

Authors: K R Elliott; C I Pogson
Journal: Biochem J Date: 1977-05-15 Impact factor: 3.857

28 in total

1. Evaluation of inhibitory guanine nucleotide regulatory protein Gi function in hepatocyte and liver membranes from obese Zucker (fa/fa) rats and their lean (Fa/?) littermates.

Authors: P Young; D M Kirkham; G J Murphy; M A Cawthorne
Journal: Diabetologia Date: 1991-08 Impact factor: 10.122

2. Activation and phosphorylation of the 'dense-vesicle' high-affinity cyclic AMP phosphodiesterase by cyclic AMP-dependent protein kinase.

Authors: E Kilgour; N G Anderson; M D Houslay
Journal: Biochem J Date: 1989-05-15 Impact factor: 3.857

3. Resensitization of hepatocyte glucagon-stimulated adenylate cyclase can be inhibited when cyclic AMP phosphodiesterase inhibitors are used to elevate intracellular cyclic AMP concentrations to supraphysiological values.

Authors: G J Murphy; M D Houslay
Journal: Biochem J Date: 1988-01-15 Impact factor: 3.857

4. Hormonal regulation of Gi2 alpha-subunit phosphorylation in intact hepatocytes.

Authors: M Bushfield; G J Murphy; B E Lavan; P J Parker; V J Hruby; G Milligan; M D Houslay
Journal: Biochem J Date: 1990-06-01 Impact factor: 3.857

5. The pathway of ketogenesis in rumen epithelium of the sheep.

Authors: B Leighton; A R Nicholas; C I Pogson
Journal: Biochem J Date: 1983-12-15 Impact factor: 3.857

6. Characterization of the phosphorylated form of the insulin-stimulated cyclic AMP phosphodiesterase from rat liver plasma membranes.

Authors: R J Marchmont; M D Houslay
Journal: Biochem J Date: 1981-06-01 Impact factor: 3.857

10. A mnemonical or negative-co-operativity model for the activation of adenylate cyclase by a common G-protein-coupled calcitonin-gene-related neuropeptide (CGRP)/amylin receptor.

Authors: M Bushfield; A Savage; N J Morris; M D Houslay
Journal: Biochem J Date: 1993-07-01 Impact factor: 3.857