Literature DB >> 880209

Expression of alpha-D-mannosidase in man-hamster somatic cell hybrids.

P H Ingram, G A Bruns, V M Regina, R E Eisenman, P S Gerald.   

Abstract

Two types of alpha-D-mannosidase isozymes are present in human white blood cells, human diploid fibroblasts, and HeLa cells. One of these (the S isozyme) constitutes the major alpha-D-mannosidase of the human cells, has a pH optimum of 4.4, and is associated with lysosomes. The other (the F isozyme) is most active at pH 6, is acid labile, and is located in the soluble portion of the cytoplasm. The expression of human lysosomal alpha-D-mannosidase was examined in man-hamster hybrid clones, and was found to be concordant with that of phosphohexose isomerase in 54 of 55 primary clones. A locus specifying human lysosomal alpha-D-mannosidase has therfore been assigned to chromosome 19.

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Year:  1977        PMID： 880209     DOI： 10.1007/bf00520191

Source DB:  PubMed          Journal:  Biochem Genet        ISSN： 0006-2928            Impact factor:   1.890


  33 in total

1.  Tissue fractionation studies. VII. Release of bound hydrolases by means of triton X-100.

Authors:  C DE DUVE; R WATTIAUX
Journal:  Biochem J       Date:  1956-08       Impact factor: 3.857

2.  The relationship between different forms of human alpha-mannosidase.

Authors:  M A Chester; A Lundblad; P K Masson
Journal:  Biochim Biophys Acta       Date:  1975-06-24

3.  The abnormalities of lysosomal enzymes in mucopolysacc- haridoses.

Authors:  F Van Hoof; H G Hers
Journal:  Eur J Biochem       Date:  1968-12

4.  The use of drug-resistant markers to study the hybridization of mouse fibroblasts.

Authors:  J W Littlefield
Journal:  Exp Cell Res       Date:  1966-01       Impact factor: 3.905

5.  Mannosidosis: a clinical and histopathologic study.

Authors:  B Kjellman; I Gamstorp; A Brun; P A Ockerman; B Palmgren
Journal:  J Pediatr       Date:  1969-09       Impact factor: 4.406

6.  Mannosidosis: deficiency of a specific alpha-mannosidase component in cultured fibroblasts.

Authors:  H A Taylor; G H Thomas; A Aylsworth; R E Stevenson; L W Reynolds
Journal:  Clin Chim Acta       Date:  1975-02-22       Impact factor: 3.786

7.  Assignment of the AK1:Np:ABO linkage group to human chromosome 9.

Authors:  A Westerveld; A P Jongsma; P Meera Khan; H van Someren; D Bootsma
Journal:  Proc Natl Acad Sci U S A       Date:  1976-03       Impact factor: 11.205

8.  Improved techniques for the induction of mammalian cell hybridization by polyethylene glycol.

Authors:  R L Davidson; P S Gerald
Journal:  Somatic Cell Genet       Date:  1976-03

9.  Loss of human genetic markers in man--Chinese hamster somatic cell hybrids.

Authors:  A Westerveld; R P Visser; P Meera Khan; D Bootsma
Journal:  Nat New Biol       Date:  1971-11-03

10.  Isolation of mammalian cell mutants deficient in glucose-6-phosphate dehydrogenase activity: linkage to hypoxanthine phosphoribosyl transferase.

Authors:  M Rosenstraus; L A Chasin
Journal:  Proc Natl Acad Sci U S A       Date:  1975-02       Impact factor: 11.205
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  6 in total

1.  Localisation of genetic markers and orientation of the linkage group on chromosome 19.

Authors:  J D Brook; D J Shaw; L Meredith; G A Bruns; P S Harper
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

2.  Human lysosomal genes: arylsulfatase A and beta-galactosidase.

Authors:  G A Bruns; B J Mintz; A C Leary; V M Regina; P S Gerald
Journal:  Biochem Genet       Date:  1979-12       Impact factor: 1.890

3.  Isolation and sequence of a human apolipoprotein CII cDNA clone and its use to isolate and map to human chromosome 19 the gene for apolipoprotein CII.

Authors:  C L Jackson; G A Bruns; J L Breslow
Journal:  Proc Natl Acad Sci U S A       Date:  1984-05       Impact factor: 11.205

4.  Genetic variation for prolidase (PEP-4) in the mouse maps near the gene for glucosephosphate isomerase (GPI-1) on chromosome 7.

Authors:  L C Skow
Journal:  Biochem Genet       Date:  1981-08       Impact factor: 1.890

5.  Further regional localization of the genes for human acid alpha glucosidase (GAA), peptidase D (PEPD), and alpha mannosidase B (MANB) by somatic cell hybridization.

Authors:  F Martiniuk; A Ellenbogen; K Hirschhorn; R Hirschhorn
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

6.  Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

Authors:  A Ullrich; A Gray; A W Tam; T Yang-Feng; M Tsubokawa; C Collins; W Henzel; T Le Bon; S Kathuria; E Chen
Journal:  EMBO J       Date:  1986-10       Impact factor: 11.598
  6 in total

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