Literature DB >> 8795276

Synthesis and tryptic hydrolysis of p-guanidinophenyl esters derived from amino acids and peptides.

H Sekizaki1, K Itoh, E Toyota, K Tanizawa.   

Abstract

A facile synthetic method for p-guanidinophenyl esters derived from a variety of amino acids and peptides, including D-amino acids, is presented. The kinetic behavior of trypsin towards these synthetic esters, inverse substrates, was analyzed. The spatial requirement of the enzyme active site for catalytic efficiency is discussed based on the steric characteristics of the substrates.

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Year:  1996        PMID： 8795276     DOI： 10.1248/cpb.44.1577

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  2 in total

1.  Enzyme-specific activation versus leaving group ability.

Authors:  Roseri J A C de Beer; Berry Bögels; Gijs Schaftenaar; Barbara Zarzycka; Peter J L M Quaedflieg; Floris L van Delft; Sander B Nabuurs; Floris P J T Rutjes
Journal:  Chembiochem       Date:  2012-07-23       Impact factor: 3.164

2.  Simple preparation of pacific cod trypsin for enzymatic Peptide synthesis.

Authors:  Tomoyoshi Fuchise; Haruo Sekizaki; Hideki Kishimura; Sappasith Klomklao; Sitthipong Nalinanon; Soottawat Benjakul; Byung-Soo Chun
Journal:  J Amino Acids       Date:  2011-09-19
  2 in total

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