Literature DB >> 8795241

Fungal biotransformation of the antihistamine azatadine by Cunninghamella elegans.

D Zhang1, E B Hansen, J Deck, T M Heinze, J B Sutherland, C E Cerniglia.   

Abstract

The metabolism of the antihistamine azatadine by the zygomycete fungus Cunninghamella elegans ATCC 9245 was investigated. Within 72 h from the addition of the drug to 48-h-old cultures grown in Sabouraud dextrose broth, 95% of azatadine was biotransformed. Two major metabolites, 7-hydroxyazatadine (25%) and 8-hydroxyazatadine (50%), and two minor metabolites, N-desmethylazatadine and 9-hydroxyazatadine, were isolated by high-performance liquid chromatography and characterized by mass spectrometric and proton nuclear magnetic resonance spectroscopic analyses.

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Year:  1996        PMID： 8795241      PMCID： PMC168147          DOI： 10.1128/aem.62.9.3477-3479.1996

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  13 in total

1.  Treatment of acquired cold urticaria with azatadine.

Authors:  A R Ahmed; R Moy
Journal:  Australas J Dermatol       Date:  1981-08       Impact factor: 2.875

2.  Effect of azatadine on human performance.

Authors:  D K Luscombe; P J Nicholls; P S Spencer
Journal:  Br J Clin Pract       Date:  1980-03

3.  Identification and differentiation of alkylamine antihistamines and their metabolites in urine by computerized gas chromatography-mass spectrometry.

Authors:  H Maurer; K Pfleger
Journal:  J Chromatogr       Date:  1988-08-19

4.  The pharmacology of azatadine, a potential antiallergy drug.

Authors:  S Tozzi; F E Roth; I I Tabachnick
Journal:  Agents Actions       Date:  1974-10

5.  Effects of azatadine maleate on subjective appraisal and psychomotor functions relevant to driving performance.

Authors:  B Biehl
Journal:  Curr Med Res Opin       Date:  1979       Impact factor: 2.580

6.  Biotransformation of chlorpromazine and methdilazine by Cunninghamella elegans.

Authors:  D Zhang; J P Freeman; J B Sutherland; A E Walker; Y Yang; C E Cerniglia
Journal:  Appl Environ Microbiol       Date:  1996-03       Impact factor: 4.792

7.  Microbial transformation of the antihistamine pyrilamine maleate. Formation of potential mammalian metabolites.

Authors:  E B Hansen; C E Cerniglia; W A Korfmacher; D W Miller; R H Heflich
Journal:  Drug Metab Dispos       Date:  1987 Jan-Feb       Impact factor: 3.922

8.  Microbial transformation of the antihistaminic drug triprolidine hydrochloride.

Authors:  E B Hansen; R H Heflich; W A Korfmacher; D W Miller; C E Cerniglia
Journal:  J Pharm Sci       Date:  1988-03       Impact factor: 3.534

9.  Relieving symptoms of upper respiratory allergies and the common cold: azatadine maleate/pseudoephedrine sulfate syrup versus placebo.

Authors:  I Kaminszczik; L Barbon
Journal:  J Int Med Res       Date:  1983       Impact factor: 1.671

10.  Fungal transformations of antihistamines: metabolism of methapyrilene, thenyldiamine and tripelennamine to N-oxide and N-demethylated derivatives.

Authors:  C E Cerniglia; E B Hansen; K J Lambert; W A Korfmacher; D W Miller
Journal:  Xenobiotica       Date:  1988-03       Impact factor: 1.908
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  1 in total

1.  Transformation of amoxapine by Cunninghamella elegans.

Authors:  J D Moody; D Zhang; T M Heinze; C E Cerniglia
Journal:  Appl Environ Microbiol       Date:  2000-08       Impact factor: 4.792
  1 in total

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