Literature DB >> 8794935

Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy.

N R Richardson1, D C Roberts.   

Abstract

Drug self-administration studies have recently employed progressive ratio (PR) schedules to examine psychostimulant and opiate reinforcement. This review addresses the technical, statistical, and theoretical issues related to the use of the PR schedule in self-administration studies in rats. Session parameters adopted for use in our laboratory and the considerations relevant to them are described. The strengths and weaknesses of the PR schedule are also discussed.

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Year:  1996        PMID： 8794935     DOI： 10.1016/0165-0270(95)00153-0

Source DB:  PubMed          Journal:  J Neurosci Methods        ISSN： 0165-0270            Impact factor:   2.390


  577 in total

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