Literature DB >> 8792664

Anti-inflammatory and anti-nociceptive activity of disodium glycyrrhetinic acid hemiphthalate.

G Khaksa1, M E Zolfaghari, A R Dehpour, T Samadian.   

Abstract

The anti-inflammatory and anti-nociceptive effects of disodium glycyrrhetinic acid hemiphthalate (glycyrrhetinic acid 3 beta-O-hemiphthalate sodium) after parenteral administration were determined in several animal models. Disodium glycyrrhetinic acid hemiphthalate (GAP) significantly inhibited the rat paw edema induced by carrageenin (ID50 = 21.37 mg/kg), and mice writhing responses caused by acetic acid (ID50 = 9.12 mg/kg). The potency of disodium glycyrrhetinic acid hemiphthalate was about 13.05 times higher than acetylsalicylic acid in inhibiting rat paw edema and 12.84 times higher in inhibiting abdominal constrictions in mice.

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Year:  1996        PMID： 8792664     DOI： 10.1055/s-2006-957894

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  6 in total

1.  Yokukansan suppresses neuroinflammation in the hippocampus of mice and decreases the duration of lipopolysaccharide- and diazepam-mediated loss of righting reflex induced by pentobarbital.

Authors:  Kei Kawada; Tomoaki Ishida; Kohei Jobu; Shumpei Morisawa; Tetsushi Kawazoe; Motoki Nishida; Satomi Nishimura; Naohisa Tamura; Saburo Yoshioka; Mitsuhiko Miyamura
Journal:  J Nat Med       Date:  2022-03-08       Impact factor: 2.343

2.  Effect of arogh-A polyherbal formulation on the marker enzymes in isoproterenol induced myocardial injury.

Authors:  S Suchalatha; C S Shyamala Devi
Journal:  Indian J Clin Biochem       Date:  2004-07

3.  Pharmacokinetic Study of Bioactive Flavonoids in the Traditional Japanese Medicine Keigairengyoto Exerting Antibacterial Effects against Staphylococcus aureus.

Authors:  Takashi Matsumoto; Atsushi Kaneko; Junichi Koseki; Yosuke Matsubara; Setsuya Aiba; Kenshi Yamasaki
Journal:  Int J Mol Sci       Date:  2018-01-23       Impact factor: 5.923

4.  Identification of metabolites of liquiritin in rats by UHPLC-Q-TOF-MS/MS: metabolic profiling and pathway comparison in vitro and in vivo.

Authors:  Xia Zhang; Caijuan Liang; Jintuo Yin; Yupeng Sun; Lantong Zhang
Journal:  RSC Adv       Date:  2018-03-27       Impact factor: 3.361

5.  Yokukansan promotes hippocampal neurogenesis associated with the suppression of activated microglia in Gunn rat.

Authors:  Motohide Furuya; Tsuyoshi Miyaoka; Toshiko Tsumori; Kristian Liaury; Sadayuki Hashioka; Rei Wake; Keiko Tsuchie; Michiyo Fukushima; Satoko Ezoe; Jun Horiguchi
Journal:  J Neuroinflammation       Date:  2013-12-05       Impact factor: 8.322

Review 6.  Cellular Pharmacological Effects of the Traditional Japanese Kampo Medicine Yokukansan on Brain Cells.

Authors:  Kazushige Mizoguchi; Yasushi Ikarashi
Journal:  Front Pharmacol       Date:  2017-09-20       Impact factor: 5.810
  6 in total

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