| Literature DB >> 8789609 |
V G Nicoletti1, E A Tendi, C Lalicata, S Reale, A Costa, R F Villa, N Ragusa, A M Giuffrida Stella.
Abstract
The contents of subunits I, II/III, and IV of cytochrome c oxidase and of subunits alpha, beta and gamma of FoF1 ATP synthase in inner mitochondrial membrane proteins purified from cerebral cortex of rat at 2, 6, 12, 18, 24, and 26 months of age were analyzed by western blot. Age-related changes in the content of subunits, either of mitochondrial or nuclear origin, were observed. All the cytochrome c oxidase (COX) subunits examined showed an age-related increase from 2-month-old rats up to 24 months with a decrease at the oldest age (26 months). The same pattern of age-dependent changes was observed for gamma ATP synthase, while the alpha and beta subunits increased progressively up to 26 months.Entities:
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Year: 1995 PMID: 8789609 DOI: 10.1007/bf00970595
Source DB: PubMed Journal: Neurochem Res ISSN: 0364-3190 Impact factor: 3.996