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Literature DB >> 1533953

Mitochondrial genetics: a paradigm for aging and degenerative diseases?

Abstract

Studies of diseases caused by mitochondrial DNA mutations suggest that a variety of degenerative processes may be associated with defects in oxidative phosphorylation (OXPHOS). Application of this hypothesis has provided new insights into such diverse clinical problems as ischemic heart disease, late-onset diabetes, Parkinson's disease, Alzheimer's disease, and aging.

Entities: Disease

Mesh：

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Year: 1992 PMID： 1533953 DOI： 10.1126/science.1533953

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

236 in total

1. The frequency of heteroplasmy in the HVII region of mtDNA differs across tissue types and increases with age.

Authors: C D Calloway; R L Reynolds; G L Herrin; W W Anderson
Journal: Am J Hum Genet Date: 2000-03-17 Impact factor: 11.025

2. Compromised mitochondrial function leads to increased cytosolic calcium and to activation of MAP kinases.

Authors: Y Luo; J D Bond; V M Ingram
Journal: Proc Natl Acad Sci U S A Date: 1997-09-02 Impact factor: 11.205

3. Visualization of mitochondrial respiratory function using cytochrome c oxidase/succinate dehydrogenase (COX/SDH) double-labeling histochemistry.

Authors: Jaime M Ross
Journal: J Vis Exp Date: 2011-11-23 Impact factor: 1.355

Review 4. Classical and alternative components of the mitochondrial respiratory chain in pathogenic fungi as potential therapeutic targets.

Authors: Vicente de Paulo Martins; Taisa Magnani Dinamarco; Carlos Curti; Sérgio Akira Uyemura
Journal: J Bioenerg Biomembr Date: 2011-02 Impact factor: 2.945

Review 5. Energy metabolism and oxidative stress: impact on the metabolic syndrome and the aging process.

Authors: Madlyn Frisard; Eric Ravussin
Journal: Endocrine Date: 2006-02 Impact factor: 3.633

Review 6. Molecular gerontology.

Authors: T B L Kirkwood
Journal: J Inherit Metab Dis Date: 2002-05 Impact factor: 4.982

Mitochondrial genetics: a paradigm for aging and degenerative diseases?

1. The frequency of heteroplasmy in the HVII region of mtDNA differs across tissue types and increases with age.

2. Compromised mitochondrial function leads to increased cytosolic calcium and to activation of MAP kinases.

3. Visualization of mitochondrial respiratory function using cytochrome c oxidase/succinate dehydrogenase (COX/SDH) double-labeling histochemistry.

Review 4. Classical and alternative components of the mitochondrial respiratory chain in pathogenic fungi as potential therapeutic targets.

Review 5. Energy metabolism and oxidative stress: impact on the metabolic syndrome and the aging process.

Review 6. Molecular gerontology.

7. Partial outlet obstruction of the rabbit bladder results in changes in the mitochondrial genetic system.

8. Transfection of mitochondria: strategy towards a gene therapy of mitochondrial DNA diseases.

9. The complete mitochondrial DNA sequence of the crustacean Artemia franciscana.

10. Marked increase in the number and variety of mitochondrial DNA rearrangements in aging human skeletal muscle.