| Literature DB >> 8785178 |
Abstract
Ascorbic acid is a potent stimulator for type I and III collagen expression in human skin fibroblasts; stimulation of type I and III collagen synthesis and their mRNA levels by ascorbic acid has been reported previously. Nuclear run-on experiments demonstrated that ascorbic acid enhanced the transcription of type I and III collagen genes 4- and 3.4-fold respectively, whereas transcription of type IV collagen was slightly stimulated (1.7-fold). The results suggest that ascorbic acid preferentially enhanced type I and III collagen transcription.Entities:
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Year: 1996 PMID： 8785178 DOI： 10.1016/0923-1811(95)00640-0
Source DB: PubMed Journal: J Dermatol Sci ISSN： 0923-1811 Impact factor: 4.563