Literature DB >> 8778459

Human gene therapy and slippery slope arguments.

T McGleenan1.   

Abstract

Any suggestion of altering the genetic makeup of human beings through gene therapy is quite likely to provoke a response involving some reference to a 'slippery slope'. In this article the author examines the topography of two different types of slippery slope argument, the logical slippery slope and the rhetorical slippery slope argument. The logical form of the argument suggests that if we permit somatic cell gene therapy then we are committed to accepting germ line gene therapy in the future because there is no logically sustainable distinction between them. The rhetorical form posits that allowing somatic cell therapy now will be taking the first step on a slippery slope which will ultimately lead to the type of genocide perpetrated by the Nazis. The author tests the validity of these lines of argument against the facts of human gene therapy and concludes that because of their dependence on probabilities that cannot be empirically proven they should be largely disregarded in the much more important debate on moral line-drawing in gene therapy.

Entities:  

Keywords:  Analytical Approach; Clothier Committee (Great Britain); Gene Therapy Advisory Committee (Great Britain); Genetics and Reproduction; Legal Approach

Mesh:

Year:  1995        PMID: 8778459      PMCID: PMC1376832          DOI: 10.1136/jme.21.6.350

Source DB:  PubMed          Journal:  J Med Ethics        ISSN: 0306-6800            Impact factor:   2.903


  5 in total

1.  The law and practice of euthanasia in the Netherlands.

Authors:  John Keown
Journal:  Law Q Rev       Date:  1992-01

2.  The slippery-slope argument.

Authors:  W van der Burg
Journal:  J Clin Ethics       Date:  1992

3.  Euthanasia and other medical decisions concerning the end of life.

Authors:  P J Van Der Maas; J J Van Delden; L Pijnenborg; C W Looman
Journal:  Lancet       Date:  1991-09-14       Impact factor: 79.321

4.  Rationale for an integrated approach to genetic epidemiology.

Authors:  Claude M Laberge; Bartha Maria Knoppers
Journal:  Bioethics       Date:  1992-10       Impact factor: 1.898

Review 5.  Human gene therapy: ethics and public policy.

Authors:  L Walters
Journal:  Hum Gene Ther       Date:  1991       Impact factor: 5.695

  5 in total
  3 in total

Review 1.  Human gene therapy and the slippery slope argument.

Authors:  Veikko Launis
Journal:  Med Health Care Philos       Date:  2002

2.  Students' attitudes towards somatic genome editing versus genome editing of the germline using an example of familial leukemia.

Authors:  Beate Vajen; Joelle Ronez; Wiebke Rathje; Laura Heinisch; Smilla Ebeling; Ulrich Gebhard; Corinna Hößle; Brigitte Schlegelberger
Journal:  J Community Genet       Date:  2021-05-08

3.  Is selecting better than modifying? An investigation of arguments against germline gene editing as compared to preimplantation genetic diagnosis.

Authors:  Alix Lenia V Hammerstein; Matthias Eggel; Nikola Biller-Andorno
Journal:  BMC Med Ethics       Date:  2019-11-21       Impact factor: 2.652

  3 in total

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