| Literature DB >> 8777713 |
S R Wiley1, K Schooley, P J Smolak, W S Din, C P Huang, J K Nicholl, G R Sutherland, T D Smith, C Rauch, C A Smith.
Abstract
A novel tumor necrosis factor (TNF) family member has been cloned and characterized. This protein, designated TNF-related apoptosis-inducing ligand (TRAIL), consists of 281 and 291 aa in the human and murine forms, respectively, which share 65% aa identity. TRAIL is a type II membrane protein, whose C-terminal extracellular domain shows clear homology to other TNF family members. TRAIL transcripts are detected in a variety of human tissues, most predominantly in spleen, lung, and prostate. The TRAIL gene is located on chromosome 3 at position 3q26, which is not close to any other known TNF ligand family members. Both full-length cell surface expressed TRAIL and picomolar concentrations of soluble TRAIL rapidly induce apoptosis in a wide variety of transformed cell lines of diverse origin.Entities:
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Year: 1995 PMID： 8777713 DOI： 10.1016/1074-7613(95)90057-8
Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745