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Literature DB >> 8777661

Effect of non-sucrose sweet tasting solution on neonatal heel prick responses.

L A Ramenghi¹, G C Griffith, C M Wood, M I Levene.

Abstract

A substance commercially described as 'sugar free,' used as a sweetener for paracetamol suspension, was evaluated on measures of neonatal pain. Sixty infants were randomly allocated to receive one of four solutions before heel stab blood sampling: sterile water (placebo); 25 or 50% sucrose (weight/volume); and the commercial sweet-tasting solution. There was a significant reduction in crying time and pain score 3 minutes after the painful stimulus in all groups compared with the controls. It is concluded that this sweet-tasting solution has analgesic effects as potent as those of concentrated sucrose solutions.

Entities: Chemical Disease Species

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Year: 1996 PMID： 8777661 PMCID： PMC2528524 DOI： 10.1136/fn.74.2.f129

Source DB: PubMed Journal: Arch Dis Child Fetal Neonatal Ed ISSN： 1359-2998 Impact factor: 5.747

13 in total

Effect of non-sucrose sweet tasting solution on neonatal heel prick responses.

1. Neonatal facial and cry responses to invasive and non-invasive procedures.

2. The distribution of fungiform papillae and taste buds on the human tongue.

3. Interactions between sucrose, pain and isolation distress.

Review 4. Pain and its effects in the human neonate and fetus.

5. Pacifying effects of nonnutritive sucking on term and preterm neonates during heelstick procedures.

6. Effects of intra-oral sucrose on crying, mouthing and hand-mouth contact in newborn and six-week-old infants.

7. Sucrose as an analgesic for newborn infants.

8. Effect of neonatal circumcision on pain responses during vaccination in boys.

9. Pain expression in neonates: facial action and cry.

10. The analgesic effect of sucrose in full term infants: a randomised controlled trial.

1. Randomised trial of analgesic effects of sucrose, glucose, and pacifiers in term neonates.

Review 2. Assessment and management of pain in neonates.

3. Pain response in neonates.

Review 4. Sweet-tasting solutions for needle-related procedural pain in infants one month to one year of age.

Review 5. The relationship between opioid and sugar intake: review of evidence and clinical applications.

6. Randomised controlled trial of paracetamol for heel prick pain in neonates.

7. Non-sucrose sweetener for pain relief in sick newborns.

Review 8. A systematic review and meta-analyses of nonsucrose sweet solutions for pain relief in neonates.

9. "Sucrose analgesia": absorptive mechanism or taste perception?

Review 10. Sucrose for analgesia in newborn infants undergoing painful procedures.