OBJECTIVE: To evaluate the effects of different sucrose concentrations on measures of neonatal pain. DESIGN: Randomised, double blind, placebo controlled trial of sterile water (control) or one of three solutions of sucrose--namely, 12.5%, 25%, and 50% wt/vol. SETTING: Postnatal ward. PATIENTS: 60 healthy infants of gestational age 37-42 weeks and postnatal age 1-6 days randomised to receive 2 ml of one of the four solutions on to the tongue two minutes before heel prick sampling for serum bilirubin concentrations. MAIN OUTCOME MEASURE: Duration of crying over the first three minutes after heel prick. RESULTS: There was a significant reduction in overall crying time and heart rate after three minutes in the babies given 50% sucrose as compared with controls. This was maximal one minute after heel prick in the 50% sucrose group and became statistically significant in the 25% sucrose group at two minutes. There was a significant trend for a reduction in crying time with increasing concentrations of sucrose over the first three minutes. CONCLUSION:Concentrated sucrose solution seems to reduce crying and the autonomic effects of a painful procedure in healthy normal babies. Sucrose may be a useful and safe analgesic for minor procedures in neonates.
RCT Entities:
OBJECTIVE: To evaluate the effects of different sucrose concentrations on measures of neonatal pain. DESIGN: Randomised, double blind, placebo controlled trial of sterile water (control) or one of three solutions of sucrose--namely, 12.5%, 25%, and 50% wt/vol. SETTING: Postnatal ward. PATIENTS: 60 healthy infants of gestational age 37-42 weeks and postnatal age 1-6 days randomised to receive 2 ml of one of the four solutions on to the tongue two minutes before heel prick sampling for serum bilirubin concentrations. MAIN OUTCOME MEASURE: Duration of crying over the first three minutes after heel prick. RESULTS: There was a significant reduction in overall crying time and heart rate after three minutes in the babies given 50% sucrose as compared with controls. This was maximal one minute after heel prick in the 50% sucrose group and became statistically significant in the 25% sucrose group at two minutes. There was a significant trend for a reduction in crying time with increasing concentrations of sucrose over the first three minutes. CONCLUSION: Concentrated sucrose solution seems to reduce crying and the autonomic effects of a painful procedure in healthy normal babies. Sucrose may be a useful and safe analgesic for minor procedures in neonates.
Authors: E C C Rebouças; E N Segato; R Kishi; R L Freitas; M Savoldi; S Morato; N C Coimbra Journal: Psychopharmacology (Berl) Date: 2004-12-10 Impact factor: 4.530
Authors: S Ogawa; T Ogihara; E Fujiwara; K Ito; M Nakano; S Nakayama; T Hachiya; N Fujimoto; H Abe; S Ban; E Ikeda; H Tamai Journal: Arch Dis Child Fetal Neonatal Ed Date: 2005-05-04 Impact factor: 5.747