Literature DB >> 877573

Perilla ketone: a potent lung toxin from the mint plant, Perilla frutescens Britton.

B J Wilson, J E Garst, R D Linnabary, R B Channell.   

Abstract

Perilla ketone, from the essential oil of Perilla frutescens, is a potent pulmonary edemagenic agent for laboratory animals and livestock. This finding would account for reported effects of the plant on grazing cattle. The use of perilla in oriental foods and medicinal preparations suggests possible hazards to human health as well.

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Year:  1977        PMID： 877573     DOI： 10.1126/science.877573

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  4 in total

1.  Bioactivation of 4-Ipomeanol by a CYP4B enzyme in bovine lung and inhibition by HET0016.

Authors:  O T Parkinson; E J Kelly; E Bezabih; D Whittington; A E Rettie
Journal:  J Vet Pharmacol Ther       Date:  2011-09-15       Impact factor: 1.786

2.  Morphology of noncardiogenic pulmonary edema induced by Perilla ketone in sheep.

Authors:  M L Guerry-Force; J Coggeshall; J Snapper; B Meyrick
Journal:  Am J Pathol       Date:  1988-11       Impact factor: 4.307

3.  Optimized human CYP4B1 in combination with the alkylator prodrug 4-ipomeanol serves as a novel suicide gene system for adoptive T-cell therapies.

Authors:  K Roellecke; E L Virts; R Einholz; K Z Edson; B Altvater; C Rossig; D von Laer; K Scheckenbach; M Wagenmann; D Reinhardt; C M Kramm; A E Rettie; C Wiek; H Hanenberg
Journal:  Gene Ther       Date:  2016-05-19       Impact factor: 5.250

Review 4.  Metabolic activation and lung toxicity: a basis for cell-selective pulmonary damage by foreign chemicals.

Authors:  M R Boyd
Journal:  Environ Health Perspect       Date:  1984-04       Impact factor: 9.031
  4 in total

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