Literature DB >> 21919916

Bioactivation of 4-Ipomeanol by a CYP4B enzyme in bovine lung and inhibition by HET0016.

O T Parkinson1, E J Kelly, E Bezabih, D Whittington, A E Rettie.   

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Year:  2011        PMID： 21919916      PMCID： PMC3423095          DOI： 10.1111/j.1365-2885.2011.01339.x

Source DB:  PubMed          Journal:  J Vet Pharmacol Ther        ISSN： 0140-7783            Impact factor:   1.786


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  15 in total

1.  HET0016, a potent and selective inhibitor of 20-HETE synthesizing enzyme.

Authors:  N Miyata; K Taniguchi; T Seki; T Ishimoto; M Sato-Watanabe; Y Yasuda; M Doi; S Kametani; Y Tomishima; T Ueki; M Sato; K Kameo
Journal:  Br J Pharmacol       Date:  2001-06       Impact factor: 8.739

2.  The rabbit pulmonary monooxygenase system. Immunochemical and biochemical characterization of enzyme components.

Authors:  C J Serabjit-Singh; C R Wolf; R M Philpot
Journal:  J Biol Chem       Date:  1979-10-10       Impact factor: 5.157

3.  Expression and characterization of CYP4V2 as a fatty acid omega-hydroxylase.

Authors:  Mariko Nakano; Edward J Kelly; Allan E Rettie
Journal:  Drug Metab Dispos       Date:  2009-08-06       Impact factor: 3.922

4.  Tissue- and species-dependent expression of sheep lung microsomal cytochrome P4502B(LgM2).

Authors:  E Arinç; I Hanukoglu; A Sen; O Adali
Journal:  Biochem Mol Biol Int       Date:  1995-12

5.  Species-dependent expression and induction of homologues of rabbit cytochrome P-450 isozyme 5 in liver and lung.

Authors:  R R Vanderslice; B A Domin; G T Carver; R M Philpot
Journal:  Mol Pharmacol       Date:  1987-04       Impact factor: 4.436

6.  In vitro metabolic activation of the pulmonary toxin, 4-ipomeanol, in nonciliated bronchiolar epithelial (Clara) and alveolar type II cells isolated from rabbit lung.

Authors:  T R Devereux; K G Jones; J R Bend; J R Fouts; C N Statham; M R Boyd
Journal:  J Pharmacol Exp Ther       Date:  1982-01       Impact factor: 4.030

7.  The relationship between increases in the hepatic content of cytochrome P-450, form 5, and in the metabolism of aromatic amines to mutagenic products following treatment of rabbits with phenobarbital.

Authors:  I G Robertson; C Serabjit-Singh; J E Croft; R M Philpot
Journal:  Mol Pharmacol       Date:  1983-07       Impact factor: 4.436

8.  Effects of 4-ipomeanol, a product from mold-damaged sweet potatoes, on the bovine lung.

Authors:  A R Doster; F E Mitchell; R L Farrell; B J Wilson
Journal:  Vet Pathol       Date:  1978-05       Impact factor: 2.221

9.  CYP4 isozyme specificity and the relationship between omega-hydroxylation and terminal desaturation of valproic acid.

Authors:  A E Rettie; P R Sheffels; K R Korzekwa; F J Gonzalez; R M Philpot; T A Baillie
Journal:  Biochemistry       Date:  1995-06-20       Impact factor: 3.162

10.  CYP4B1 activates 4-ipomeanol in rat lung.

Authors:  R D Verschoyle; R M Philpot; C R Wolf; D Dinsdale
Journal:  Toxicol Appl Pharmacol       Date:  1993-12       Impact factor: 4.219
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  5 in total

1.  Generation and characterization of a Cyp4b1 null mouse and the role of CYP4B1 in the activation and toxicity of Ipomeanol.

Authors:  Oliver T Parkinson; H Denny Liggitt; Allan E Rettie; Edward J Kelly
Journal:  Toxicol Sci       Date:  2013-06-07       Impact factor: 4.849

2.  Species Differences in Microsomal Oxidation and Glucuronidation of 4-Ipomeanol: Relationship to Target Organ Toxicity.

Authors:  Oliver T Parkinson; Aaron M Teitelbaum; Dale Whittington; Edward J Kelly; Allan E Rettie
Journal:  Drug Metab Dispos       Date:  2016-07-28       Impact factor: 3.922

Review 3.  CYP4 enzymes as potential drug targets: focus on enzyme multiplicity, inducers and inhibitors, and therapeutic modulation of 20-hydroxyeicosatetraenoic acid (20-HETE) synthase and fatty acid ω-hydroxylase activities.

Authors:  Katheryne Z Edson; Allan E Rettie
Journal:  Curr Top Med Chem       Date:  2013       Impact factor: 3.295

Review 4.  Cytochrome P450 ω-Hydroxylases in Inflammation and Cancer.

Authors:  Amanda L Johnson; Katheryne Z Edson; Rheem A Totah; Allan E Rettie
Journal:  Adv Pharmacol       Date:  2015-06-27

5.  Expression and Functional Characterization of Breast Cancer-Associated Cytochrome P450 4Z1 in Saccharomyces cerevisiae.

Authors:  Matthew G McDonald; Sutapa Ray; Clara J Amorosi; Katherine A Sitko; John P Kowalski; Lorela Paco; Abhinav Nath; Byron Gallis; Rheem A Totah; Maitreya J Dunham; Douglas M Fowler; Allan E Rettie
Journal:  Drug Metab Dispos       Date:  2017-10-10       Impact factor: 3.922
  5 in total

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