Literature DB >> 8773759

Distribution of aluminum in different brain regions and body organs of rat.

D Julka1, R K Vasishta, K D Gill.   

Abstract

In the present study, an attempt has been made to investigate the distribution of aluminum in different regions of brain and body organs of male albino rats, following subacute and acute aluminum exposure. Aluminum was observed to accumulate in all regions of the brain with maximum accumulation in the hippocampus. Subcellular distribution of aluminum indicated that there was maximum localization in the nucleus followed by cytosolic, microsomal, and mitochondrial deposition. Elution profile of cytosolic proteins on G-75 Sephadex column revealed a substantial amount of aluminum bound to high-mol-wt protein fraction. Aluminum was also seen to compartmentalize in almost all the tissues of the body to varying extents, and the highest accumulation was in the spleen.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8773759     DOI： 10.1007/BF02789460

Source DB:  PubMed          Journal:  Biol Trace Elem Res        ISSN： 0163-4984            Impact factor:   3.738


  28 in total

1.  Inhibition of protein kinase C activation by low concentrations of aluminium.

Authors:  M Cochran; D C Elliott; P Brennan; V Chawtur
Journal:  Clin Chim Acta       Date:  1990-12-24       Impact factor: 3.786

2.  Plasmapheresis, aluminium, and dialysis dementia.

Authors:  H L Elliott; A I Macdougall; G S Fell; P H Gardiner
Journal:  Lancet       Date:  1978-12-09       Impact factor: 79.321

3.  Aluminum reduction and bladder cancer.

Authors:  G C Dunkley
Journal:  Can Med Assoc J       Date:  1982-05-01       Impact factor: 8.262

4.  Aluminum access to the brain: a role for transferrin and its receptor.

Authors:  A J Roskams; J R Connor
Journal:  Proc Natl Acad Sci U S A       Date:  1990-11       Impact factor: 11.205

5.  Aluminum-associated hepatobiliary dysfunction in rats: relationships to dosage and duration of exposure.

Authors:  G L Klein; M B Heyman; T C Lee; N L Miller; G Marathe; W K Gourley; A C Alfrey
Journal:  Pediatr Res       Date:  1988-03       Impact factor: 3.756

6.  Liver, kidney, and central nervous system toxicity of aluminum given intraperitoneally to rats: a multiple-dose subchronic study using aluminum nitrilotriacetate.

Authors:  Y Ebina; S Okada; S Hamazaki; O Midorikawa
Journal:  Toxicol Appl Pharmacol       Date:  1984-09-15       Impact factor: 4.219

7.  Aluminum interaction with calmodulin. Evidence for altered structure and function from optical and enzymatic studies.

Authors:  N Siegel; A Haug
Journal:  Biochim Biophys Acta       Date:  1983-04-14

8.  Assessment of exposure to parenteral and oral aluminum with and without citrate using a desferrioxamine test in rats.

Authors:  J L Greger; C F Powers
Journal:  Toxicology       Date:  1992-11-30       Impact factor: 4.221

Review 9.  Molecular studies in Alzheimer's disease.

Authors:  D M Holtzman; W C Mobley
Journal:  Trends Biochem Sci       Date:  1991-04       Impact factor: 13.807

Review 10.  Metabolism and possible health effects of aluminum.

Authors:  P O Ganrot
Journal:  Environ Health Perspect       Date:  1986-03       Impact factor: 9.031
View more
  10 in total

1.  The possible neuroprotective effects of melatonin in aluminum chloride-induced neurotoxicity via antioxidant pathway and Nrf2 signaling apart from metal chelation.

Authors:  Kadry M Sadek; Mohamed A Lebda; Tarek K Abouzed
Journal:  Environ Sci Pollut Res Int       Date:  2019-02-04       Impact factor: 4.223

Review 2.  Neurotoxic effects of aluminium exposure as a potential risk factor for Alzheimer's disease.

Authors:  Mangaldeep Dey; Rakesh Kumar Singh
Journal:  Pharmacol Rep       Date:  2022-01-27       Impact factor: 3.024

3.  Run-on gene transcription in human neocortical nuclei. Inhibition by nanomolar aluminum and implications for neurodegenerative disease.

Authors:  W J Lukiw; H J LeBlanc; L A Carver; D R McLachlan; N G Bazan
Journal:  J Mol Neurosci       Date:  1998-08       Impact factor: 3.444

4.  Cholinergic system under aluminium toxicity in rat brain.

Authors:  K Yellamma; S Saraswathamma; B Nirmala Kumari
Journal:  Toxicol Int       Date:  2010-07

5.  Modulatory role of simvastatin against aluminium chloride-induced behavioural and biochemical changes in rats.

Authors:  Madhavan Nampoothiri; Jessy John; Nitesh Kumar; Jayesh Mudgal; Gopalan Kutty Nampurath; Mallikarjuna Rao Chamallamudi
Journal:  Behav Neurol       Date:  2015-01-31       Impact factor: 3.342

6.  Reduction of adult hippocampal neurogenesis is amplified by aluminum exposure in a model of type 2 diabetes.

Authors:  Sung Min Nam; Jong Whi Kim; Dae Young Yoo; Hyo Young Jung; Jung Hoon Choi; In Koo Hwang; Je Kyung Seong; Yeo Sung Yoon
Journal:  J Vet Sci       Date:  2016-03-22       Impact factor: 1.672

7.  Response of regional brain glutamate transaminases of rat to aluminum in protein malnutrition.

Authors:  Prasunpriya Nayak; Ajay K Chatterjee
Journal:  BMC Neurosci       Date:  2002-08-28       Impact factor: 3.288

8.  Dietary protein restriction causes modification in aluminum-induced alteration in glutamate and GABA system of rat brain.

Authors:  Prasunpriya Nayak; Ajay K Chatterjee
Journal:  BMC Neurosci       Date:  2003-02-25       Impact factor: 3.288

9.  The Effect of Aluminum Exposure on Reproductive Ability in the Bank Vole (Myodes glareolus).

Authors:  Agata Miska-Schramm; Joanna Kapusta; Małgorzata Kruczek
Journal:  Biol Trace Elem Res       Date:  2016-09-29       Impact factor: 3.738

10.  Vitis vinifera acts as anti-Alzheimer's agent by modulating biochemical parameters implicated in cognition and memory.

Authors:  Deepthi Rapaka; Veera Raghavulu Bitra; T Chandi Vishala; Annapurna Akula
Journal:  J Ayurveda Integr Med       Date:  2018-10-15
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.