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Literature DB >> 1877089

Molecular studies in Alzheimer's disease.

Abstract

In the past decade, there has been an explosion of information relating to the molecular neurobiology of Alzheimer's disease (AD). Molecular dissection of the neuropathology of AD has provided insight into the pathogenesis of this disease and has defined areas where investigation may prove useful in elucidating the cause of this disorder and suggest new treatments.

Entities: Disease

Mesh：

Year: 1991 PMID： 1877089 DOI： 10.1016/0968-0004(91)90056-2

Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807

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Cited

9 in total

1. A two-step strategy for structure-activity relationship studies of N-methylated aβ42 C-terminal fragments as aβ42 toxicity inhibitors.

Authors: Huiyuan Li; Reeve Zemel; Dahabada H J Lopes; Bernhard H Monien; Gal Bitan
Journal: ChemMedChem Date: 2012-02-03 Impact factor: 3.466

2. Distribution of aluminum in different brain regions and body organs of rat.

Authors: D Julka; R K Vasishta; K D Gill
Journal: Biol Trace Elem Res Date: 1996-05 Impact factor: 3.738

3. Tissue-specific expression of dominant negative mutant Drosophila HSC70 causes developmental defects and lethality.

Authors: F Elefant; K B Palter
Journal: Mol Biol Cell Date: 1999-07 Impact factor: 4.138

4. Alzheimer beta/A4 amyloid precursor protein in human brain: aging-associated increases in holoprotein and in a proteolytic fragment.

Authors: C Nordstedt; S E Gandy; I Alafuzoff; G L Caporaso; K Iverfeldt; J A Grebb; B Winblad; P Greengard
Journal: Proc Natl Acad Sci U S A Date: 1991-10-15 Impact factor: 11.205

Molecular studies in Alzheimer's disease.

1. A two-step strategy for structure-activity relationship studies of N-methylated aβ42 C-terminal fragments as aβ42 toxicity inhibitors.

2. Distribution of aluminum in different brain regions and body organs of rat.

3. Tissue-specific expression of dominant negative mutant Drosophila HSC70 causes developmental defects and lethality.

4. Alzheimer beta/A4 amyloid precursor protein in human brain: aging-associated increases in holoprotein and in a proteolytic fragment.

Review 5. Neuropathobiology of senile dementia and mechanism of action of nootropic drugs.

6. Mouse model of neurodegeneration: atrophy of basal forebrain cholinergic neurons in trisomy 16 transplants.

7. Dysregulation of gene expression in mouse trisomy 16, an animal model of Down syndrome.

8. Effect of alanine replacement of l17 and f19 on the aggregation and neurotoxicity of arctic-type aβ40.

9. Control of pre-mRNA splicing by the general splicing factors PUF60 and U2AF(65).