Literature DB >> 8769136

Molecular characterization of AKAP149, a novel A kinase anchor protein with a KH domain.

G Trendelenburg1, M Hummel, E O Riecken, C Hanski.   

Abstract

The cytosolic cAMP activates in eukaryotic cells several isoforms of cAMP-dependent protein kinase (PKAs) involved in signal transduction. The effects of individual PKA isoforms are determined by their cellular localisation, specified through binding to distinct A Kinase Anchor Proteins (AKAPs). A new member of the AKAP family, a membrane-anchored 903 amino acid long protein, designated AKAP149, is characterized in the present work. It is a putative splicing variant of S-AKAP84 with the important new feature of a RNA-binding motif (KH domain). This domain together with the known characteristics of AKAPs suggests the involvement of AKAP149 in the phosphorylation-dependent regulation of RNA-processing.

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Year:  1996        PMID： 8769136     DOI： 10.1006/bbrc.1996.1172

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  12 in total

1.  Identification of a cytoskeleton-associated 120 kDa RNA-binding protein in developing rice seeds.

Authors:  R Sami-Subbu; S B Choi; Y Wu; C Wang; T W Okita
Journal:  Plant Mol Biol       Date:  2001-05       Impact factor: 4.076

Review 2.  The role of serine/threonine protein phosphatases in exocytosis.

Authors:  Alistair T R Sim; Monique L Baldwin; John A P Rostas; Jeff Holst; Russell I Ludowyke
Journal:  Biochem J       Date:  2003-08-01       Impact factor: 3.857

Review 3.  Networking with AKAPs: context-dependent regulation of anchored enzymes.

Authors:  Emily J Welch; Brian W Jones; John D Scott
Journal:  Mol Interv       Date:  2010-04

4.  Mitochondrial AKAP121 links cAMP and src signaling to oxidative metabolism.

Authors:  Alessandra Livigni; Antonella Scorziello; Savina Agnese; Annagrazia Adornetto; Annalisa Carlucci; Corrado Garbi; Imma Castaldo; Lucio Annunziato; Enrico V Avvedimento; Antonio Feliciello
Journal:  Mol Biol Cell       Date:  2005-10-26       Impact factor: 4.138

5.  Mitochondrial AKAP121 binds and targets protein tyrosine phosphatase D1, a novel positive regulator of src signaling.

Authors:  Luca Cardone; Annalisa Carlucci; Adele Affaitati; Alessandra Livigni; Tiziana DeCristofaro; Corrado Garbi; Stelio Varrone; Axel Ullrich; Max E Gottesman; Enrico V Avvedimento; Antonio Feliciello
Journal:  Mol Cell Biol       Date:  2004-06       Impact factor: 4.272

6.  Reverse Transcriptase and Cellular Factors: Regulators of HIV-1 Reverse Transcription.

Authors:  Kylie Warren; David Warrilow; Luke Meredith; David Harrich
Journal:  Viruses       Date:  2009-11-10       Impact factor: 5.048

7.  NH2-Terminal targeting motifs direct dual specificity A-kinase-anchoring protein 1 (D-AKAP1) to either mitochondria or endoplasmic reticulum.

Authors:  L J Huang; L Wang; Y Ma; K Durick; G Perkins; T J Deerinck; M H Ellisman; S S Taylor
Journal:  J Cell Biol       Date:  1999-05-31       Impact factor: 10.539

8.  Recruitment of protein phosphatase 1 to the nuclear envelope by A-kinase anchoring protein AKAP149 is a prerequisite for nuclear lamina assembly.

Authors:  R L Steen; S B Martins; K Taskén; P Collas
Journal:  J Cell Biol       Date:  2000-09-18       Impact factor: 10.539

9.  Detection of novel members, structure-function analysis and evolutionary classification of the 2H phosphoesterase superfamily.

Authors:  Raja Mazumder; Lakshminarayan M Iyer; Sona Vasudevan; L Aravind
Journal:  Nucleic Acids Res       Date:  2002-12-01       Impact factor: 16.971

10.  A map of human protein interactions derived from co-expression of human mRNAs and their orthologs.

Authors:  Arun K Ramani; Zhihua Li; G Traver Hart; Mark W Carlson; Daniel R Boutz; Edward M Marcotte
Journal:  Mol Syst Biol       Date:  2008-04-15       Impact factor: 11.429
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