Literature DB >> 20368369

Networking with AKAPs: context-dependent regulation of anchored enzymes.

Emily J Welch1, Brian W Jones, John D Scott.   

Abstract

A-Kinase Anchoring Proteins (AKAPs) orchestrate and synchronize cellular events by tethering the cAMP-dependent protein kinase (PKA) and other signaling enzymes to organelles and membranes. The control of kinases and phosphatases that are held in proximity to activators, effectors, and substrates favors the rapid dissemination of information from one cellular location to the next. This article charts the inception of the PKA-anchoring hypothesis, the characterization of AKAPs and their nomenclature, and the physiological roles of context-specific AKAP signaling complexes.

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Year:  2010        PMID： 20368369      PMCID： PMC2895371          DOI： 10.1124/mi.10.2.6

Source DB:  PubMed          Journal:  Mol Interv        ISSN： 1534-0384


  168 in total

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Authors:  Joanne T Hulme; Misol Ahn; Stephen D Hauschka; Todd Scheuer; William A Catterall
Journal:  J Biol Chem       Date:  2001-11-30       Impact factor: 5.157

2.  The cardiac IKs potassium channel macromolecular complex includes the phosphodiesterase PDE4D3.

Authors:  Cecile Terrenoire; Miles D Houslay; George S Baillie; Robert S Kass
Journal:  J Biol Chem       Date:  2009-02-13       Impact factor: 5.157

3.  An adenylyl cyclase-mAKAPbeta signaling complex regulates cAMP levels in cardiac myocytes.

Authors:  Michael S Kapiloff; Leslie A Piggott; Rachna Sadana; Jinliang Li; Lorena A Heredia; Edward Henson; Riad Efendiev; Carmen W Dessauer
Journal:  J Biol Chem       Date:  2009-07-01       Impact factor: 5.157

4.  Regulation of GluR1 by the A-kinase anchoring protein 79 (AKAP79) signaling complex shares properties with long-term depression.

Authors:  Steven J Tavalin; Marcie Colledge; Johannes W Hell; Lorene K Langeberg; Richard L Huganir; John D Scott
Journal:  J Neurosci       Date:  2002-04-15       Impact factor: 6.167

5.  Regulation of A-kinase anchoring protein 79/150-cAMP-dependent protein kinase postsynaptic targeting by NMDA receptor activation of calcineurin and remodeling of dendritic actin.

Authors:  Lisa L Gomez; Shuvo Alam; Karen E Smith; Eric Horne; Mark L Dell'Acqua
Journal:  J Neurosci       Date:  2002-08-15       Impact factor: 6.167

6.  The ubiquitin-like protein LC3 regulates the Rho-GEF activity of AKAP-Lbc.

Authors:  Laurent Baisamy; Sabrina Cavin; Nathalie Jurisch; Dario Diviani
Journal:  J Biol Chem       Date:  2009-08-20       Impact factor: 5.157

7.  The PKARIalpha subunit of protein kinase A modulates the activation of p90RSK1 and its function.

Authors:  Deepti Chaturvedi; Michael S Cohen; Jack Taunton; Tarun B Patel
Journal:  J Biol Chem       Date:  2009-07-01       Impact factor: 5.157

8.  Varp is a novel Rab32/38-binding protein that regulates Tyrp1 trafficking in melanocytes.

Authors:  Kanako Tamura; Norihiko Ohbayashi; Yuto Maruta; Eiko Kanno; Takashi Itoh; Mitsunori Fukuda
Journal:  Mol Biol Cell       Date:  2009-04-29       Impact factor: 4.138

Review 9.  Adenylyl cyclase--A-kinase anchoring protein complexes: the next dimension in cAMP signaling.

Authors:  Carmen W Dessauer
Journal:  Mol Pharmacol       Date:  2009-08-14       Impact factor: 4.436

10.  A-kinase anchoring in dendritic cells is required for antigen presentation.

Authors:  Robynn V Schillace; Casey L Miller; Neal Pisenti; Jeff E Grotzke; Gwendolyn M Swarbrick; David M Lewinsohn; Daniel W Carr
Journal:  PLoS One       Date:  2009-03-11       Impact factor: 3.240
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  89 in total

Review 1.  A-kinase anchoring proteins that regulate cardiac remodeling.

Authors:  Graeme K Carnegie; Brian T Burmeister
Journal:  J Cardiovasc Pharmacol       Date:  2011-11       Impact factor: 3.105

2.  An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria.

Authors:  Christopher K Means; Birgitte Lygren; Lorene K Langeberg; Ankur Jain; Rose E Dixon; Amanda L Vega; Matthew G Gold; Susanna Petrosyan; Susan S Taylor; Anne N Murphy; Taekjip Ha; Luis F Santana; Kjetil Tasken; John D Scott
Journal:  Proc Natl Acad Sci U S A       Date:  2011-11-14       Impact factor: 11.205

Review 3.  Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments.

Authors:  Thérèse Keravis; Claire Lugnier
Journal:  Br J Pharmacol       Date:  2012-03       Impact factor: 8.739

Review 4.  A-kinase anchoring proteins as potential drug targets.

Authors:  Jessica Tröger; Marie C Moutty; Philipp Skroblin; Enno Klussmann
Journal:  Br J Pharmacol       Date:  2012-05       Impact factor: 8.739

5.  The A-kinase-anchoring protein AKAP-Lbc facilitates cardioprotective PKA phosphorylation of Hsp20 on Ser(16).

Authors:  Helen V Edwards; John D Scott; George S Baillie
Journal:  Biochem J       Date:  2012-09-15       Impact factor: 3.857

Review 6.  Phosphorylation of mammalian cytochrome c and cytochrome c oxidase in the regulation of cell destiny: respiration, apoptosis, and human disease.

Authors:  Maik Hüttemann; Icksoo Lee; Lawrence I Grossman; Jeffrey W Doan; Thomas H Sanderson
Journal:  Adv Exp Med Biol       Date:  2012       Impact factor: 2.622

7.  Inhibition of striatal-enriched tyrosine phosphatase 61 in the dorsomedial striatum is sufficient to increased ethanol consumption.

Authors:  Emmanuel Darcq; Sami Ben Hamida; Su Wu; Khanky Phamluong; Viktor Kharazia; Jian Xu; Paul Lombroso; Dorit Ron
Journal:  J Neurochem       Date:  2014-03-27       Impact factor: 5.372

8.  Regulation of Gβγi-dependent PLC-β3 activity in smooth muscle: inhibitory phosphorylation of PLC-β3 by PKA and PKG and stimulatory phosphorylation of Gαi-GTPase-activating protein RGS2 by PKG.

Authors:  Ancy D Nalli; Divya P Kumar; Othman Al-Shboul; Sunila Mahavadi; John F Kuemmerle; John R Grider; Karnam S Murthy
Journal:  Cell Biochem Biophys       Date:  2014-11       Impact factor: 2.194

9.  Phosphodiesterase 10A Is Tethered to a Synaptic Signaling Complex in Striatum.

Authors:  Corina Russwurm; Doris Koesling; Michael Russwurm
Journal:  J Biol Chem       Date:  2015-03-11       Impact factor: 5.157

10.  PKA-type I selective constrained peptide disruptors of AKAP complexes.

Authors:  Yuxiao Wang; Tienhuei G Ho; Eugen Franz; Jennifer S Hermann; F Donelson Smith; Heidi Hehnly; Jessica L Esseltine; Laura E Hanold; Mandi M Murph; Daniela Bertinetti; John D Scott; Friedrich W Herberg; Eileen J Kennedy
Journal:  ACS Chem Biol       Date:  2015-03-25       Impact factor: 5.100
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