Literature DB >> 8768522

A general approach for cloning and characterizing dNDP-glucose dehydratase genes from actinomycetes.

H Decker1, S Gaisser, S Pelzer, P Schneider, L Westrich, W Wohlleben, A Bechthold.   

Abstract

Oligonucleotide primers were designed and successfully applied to amplify DNA fragments of dNDP-glucose dehydratase genes from actinomycete species producing natural compounds which contain deoxysugar moieties. The deduced amino acid sequence of the isolated fragments revealed similarity to known dNDP-glucose dehydratases. A phylogeny for the deduced proteins of the obtained fragments and for dNDP-glucose dehydratases described in the data bases was constructed. dNDP-glucose dehydratases from actinomycetes were more related to each other than to dehydratases from species of other orders. The phylogenetic analysis also revealed a close relation between dehydratases from strains producing natural compounds with similar deoxysugar moieties.

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Year:  1996        PMID： 8768522     DOI： 10.1111/j.1574-6968.1996.tb08384.x

Source DB:  PubMed          Journal:  FEMS Microbiol Lett        ISSN： 0378-1097            Impact factor:   2.742


  12 in total

1.  Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic.

Authors:  A Trefzer; S Pelzer; J Schimana; S Stockert; C Bihlmaier; H-P Fiedler; K Welzel; A Vente; A Bechthold
Journal:  Antimicrob Agents Chemother       Date:  2002-05       Impact factor: 5.191

2.  Genes for production of the enediyne antitumor antibiotic C-1027 in Streptomyces globisporus are clustered with the cagA gene that encodes the C-1027 apoprotein.

Authors:  W Liu; B Shen
Journal:  Antimicrob Agents Chemother       Date:  2000-02       Impact factor: 5.191

3.  Characterization of the amicetin biosynthesis gene cluster from Streptomyces vinaceusdrappus NRRL 2363 implicates two alternative strategies for amide bond formation.

Authors:  Gaiyun Zhang; Haibo Zhang; Sumei Li; Ji Xiao; Guangtao Zhang; Yiguang Zhu; Siwen Niu; Jianhua Ju; Changsheng Zhang
Journal:  Appl Environ Microbiol       Date:  2012-01-20       Impact factor: 4.792

4.  Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891.

Authors:  M Steffensky; A Mühlenweg; Z X Wang; S M Li; L Heide
Journal:  Antimicrob Agents Chemother       Date:  2000-05       Impact factor: 5.191

5.  Discovery of the lomaiviticin biosynthetic gene cluster in Salinispora pacifica.

Authors:  Jeffrey E Janso; Brad A Haltli; Alessandra S Eustáquio; Kerry Kulowski; Abraham J Waldman; Li Zha; Hitomi Nakamura; Valerie S Bernan; Haiyin He; Guy T Carter; Frank E Koehn; Emily P Balskus
Journal:  Tetrahedron       Date:  2014-07-08       Impact factor: 2.457

6.  Cloning and characterization of the ravidomycin and chrysomycin biosynthetic gene clusters.

Authors:  Madan K Kharel; S Eric Nybo; Micah D Shepherd; Jürgen Rohr
Journal:  Chembiochem       Date:  2010-03-01       Impact factor: 3.164

7.  Cloning of an avilamycin biosynthetic gene cluster from Streptomyces viridochromogenes Tü57.

Authors:  S Gaisser; A Trefzer; S Stockert; A Kirschning; A Bechthold
Journal:  J Bacteriol       Date:  1997-10       Impact factor: 3.490

Review 8.  Biosynthesis and function of polyacetylenes and allied natural products.

Authors:  Robert E Minto; Brenda J Blacklock
Journal:  Prog Lipid Res       Date:  2008-03-13       Impact factor: 16.195

9.  Biosynthesis of sibiromycin, a potent antitumor antibiotic.

Authors:  Wei Li; Ankush Khullar; Shenchieh Chou; Ashley Sacramo; Barbara Gerratana
Journal:  Appl Environ Microbiol       Date:  2009-03-06       Impact factor: 4.792

10.  The complete gene cluster of the antitumor agent gilvocarcin V and its implication for the biosynthesis of the gilvocarcins.

Authors:  Carsten Fischer; Fredilyn Lipata; Jürgen Rohr
Journal:  J Am Chem Soc       Date:  2003-07-02       Impact factor: 15.419
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