Literature DB >> 8766228

Some 3-hydrazono-2-indolinones and N-Mannich bases as potential anticonvulsants.

A Gürsoy1, N Karali, S Büyüktimkin, S Demirayak, A C Ekinci, H Ozer.   

Abstract

In this study a new series of 3-aryloxy/arylthioxyacetylhydrazono-2-indolinones obtained by condensation of isatin with aryloxy/arythioxyacetylhydrazines were treated with morpholine and formaldehyde to yield 1-morpholinomethyl-3-aryloxy/arylthioxyacetylhydrazono-2- indolinones. Structures of all the compounds were assigned on the basis of spectral data (UV, IR, 1H-NMR, EIMS) and elemental analyses. Anticonvulsant evaluation of the compounds revealed varying degrees of activity against pentylenentetrazole induced seizures.

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Year:  1996        PMID: 8766228

Source DB:  PubMed          Journal:  Farmaco        ISSN: 0014-827X


  3 in total

1.  Methyl 2-acetamido-2-(1-acetyl-3-hydr-oxy-2-oxoindolin-3-yl)propanoate.

Authors:  Hoong-Kun Fun; Jia Hao Goh; Yang Liu; Yan Zhang
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-03-03

2.  Synthesis of 1-Aryl-3-phenethylamino-1-propanone hydrochlorides as possible potent cytotoxic agents.

Authors:  Ebru Mete; Halise Inci Gul; Cavit Kazaz
Journal:  Molecules       Date:  2007-12-12       Impact factor: 4.411

3.  Synthesis, potential anticonvulsant and antidepressant effects of 2-(5-methyl-2,3-dioxoindolin-1-yl)acetamide derivatives.

Authors:  Xinghua Zhen; Zhou Peng; Shuilian Zhao; Yan Han; Qinghao Jin; Liping Guan
Journal:  Acta Pharm Sin B       Date:  2015-03-18       Impact factor: 11.413

  3 in total

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