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Literature DB >> 8763842

Recent developments in the design of bioreductive drugs.

W A Denny¹, W R Wilson, M P Hay.

Abstract

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Year: 1996 PMID： 8763842 PMCID： PMC2150040

Source DB: PubMed Journal: Br J Cancer Suppl ISSN： 0306-9443

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40 in total

1. Oxygen dependence of the cytotoxicity of the enediyne anti-tumour antibiotic esperamicin A1.

Authors: R M Batchelder; W R Wilson; M P Hay; W A Denny
Journal: Br J Cancer Suppl Date: 1996-07

2. Reductive chemistry of the novel hypoxia-selective cytotoxin 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide.

Authors: B D Palmer; P van Zijl; W A Denny; W R Wilson
Journal: J Med Chem Date: 1995-03-31 Impact factor: 7.446

3. Relationships between structure and kinetics of cyclization of 2-aminoaryl amides: potential prodrugs of cyclization-activated aromatic mustards.

Authors: G J Atwell; B M Sykes; C J O'Connor; W A Denny
Journal: J Med Chem Date: 1994-02-04 Impact factor: 7.446

4. Does DNA targeting affect the cytotoxicity and cell uptake of basic nitroquinoline bioreductive drugs?

Authors: B G Siim; W A Denny; W R Wilson
Journal: Int J Radiat Oncol Biol Phys Date: 1994-05-15 Impact factor: 7.038

5. Nitrobenzyl mustard quaternary salts: a new class of hypoxia-selective cytotoxins capable of releasing diffusible cytotoxins on bioreduction.

Authors: W A Denny; W R Wilson; M Tercel; P Van Zijl; S M Pullen
Journal: Int J Radiat Oncol Biol Phys Date: 1994-05-15 Impact factor: 7.038

6. Self-immolative prodrugs: candidates for antibody-directed enzyme prodrug therapy in conjunction with a nitroreductase enzyme.

Authors: A B Mauger; P J Burke; H H Somani; F Friedlos; R J Knox
Journal: J Med Chem Date: 1994-10-14 Impact factor: 7.446

7. DNA-DNA interstrand cross-linking by 2,5-bis(1-aziridinyl)-3,6-bis(carbethoxyamino)-1,4-benzoquinone: covalent structure of the dG-to-dG cross-links in calf thymus DNA and a synthetic DNA duplex.

Authors: S C Alley; P B Hopkins
Journal: Chem Res Toxicol Date: 1994 Sep-Oct Impact factor: 3.739

8. Pyrrolo[1,2-a]benzimidazole-based quinones and iminoquinones. The role of the 3-substituent on cytotoxicity.

Authors: W G Schulz; I Islam; E B Skibo
Journal: J Med Chem Date: 1995-01-06 Impact factor: 7.446

9. Bioreductive drugs for cancer therapy: the search for tumor specificity.

Authors: G E Adams; I J Stratford
Journal: Int J Radiat Oncol Biol Phys Date: 1994-05-15 Impact factor: 7.038

10. Cyclopropamitosenes: novel bioreductive anticancer agents--mechanism of action and enzymic reduction.

Authors: C J Moody; N O'Sullivan; I J Stratford; M A Stephens; P Workman; S M Bailey; A Lewis
Journal: Anticancer Drugs Date: 1994-06 Impact factor: 2.248

9 in total

1. Tricyclic [1,2,4]triazine 1,4-dioxides as hypoxia selective cytotoxins.

Authors: Michael P Hay; Kevin O Hicks; Karin Pchalek; Ho H Lee; Adrian Blaser; Frederik B Pruijn; Robert F Anderson; Sujata S Shinde; William R Wilson; William A Denny
Journal: J Med Chem Date: 2008-10-11 Impact factor: 7.446

Review 2. Molecular chemotherapy for breast cancer.

Authors: A Patterson; A L Harris
Journal: Drugs Aging Date: 1999-02 Impact factor: 3.923

3. Comparison of the nucleic acid covalent binding capacity of two nitro-substituted benzazolo[3,2-a]quinolinium salts upon enzymatic reduction.

Authors: Beatriz Zayas; Juan Beyley; Maria Terron; Marisol Cordero; Wigberto Hernandez; Antonio E Alegría; Osvaldo Cox
Journal: Toxicol In Vitro Date: 2007-03-13 Impact factor: 3.500

4. Overexpression of human NADPH:cytochrome c (P450) reductase confers enhanced sensitivity to both tirapazamine (SR 4233) and RSU 1069.

Authors: A V Patterson; M P Saunders; E C Chinje; D C Talbot; A L Harris; I J Strafford
Journal: Br J Cancer Date: 1997 Impact factor: 7.640