| Literature DB >> 7919462 |
C J Moody1, N O'Sullivan, I J Stratford, M A Stephens, P Workman, S M Bailey, A Lewis.
Abstract
The mechanism of action of cyclopropamitosenes, novel bioreductive anticancer agents, has been investigated using a unique combination of chemical and biochemical techniques. The compounds 4 function as reductively activated alkylating agents under chemical reducing conditions, and the biochemical experiments establish that the methoxy- and aziridinyl-derivatives 4a and 4b behave differently upon bioreduction.Entities:
Mesh：
Substances：
Year: 1994 PMID： 7919462
Source DB: PubMed Journal: Anticancer Drugs ISSN： 0959-4973 Impact factor: 2.248