M Aleman1, S J Spier, W D Wilson, M Doherr. 1. Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis 95616, USA.
Abstract
OBJECTIVE: To describe clinical manifestations of Corynebacterium pseudotuberculosis infection in horses and to evaluate diagnostic methods for identification of this disease. DESIGN: Retrospective case series. ANIMALS: 538 horses with a diagnosis of C pseudotuberculosis infection. RESULTS: Median age of horses with external abscesses was similar to that in horses with internal abscesses. Breed and sex did not appear to be associated with infection. Cases were detected during all 12 months; however, the disease was most common in the fall and early winter, with the highest incidence in September, October, and November in every year. Most horses (492/538, 91.4%) had a single episode of infection, without recurrence in subsequent years. Of 538 horses, 308 had pectoral abscesses, although infection was documented in many other anatomic locations. Forty-two horses had internal abscesses involving the abdomen or thoracic cavity. Corynebacterium pseudotuberculosis infection was readily identified by bacterial culture of aspirate samples from abscesses. The synergistic hemolysis inhibition test was useful for diagnosis of internal abscesses; however, it was unreliable for the diagnosis of external abscesses. Horses with external abscesses responded well to conventional treatment, in contrast to those with internal abscesses. The overall case fatality was low (3.9%), and was considerably lower for horses with external abscesses (0.8%) than for horses with internal abscesses (40.5%). CLINICAL IMPLICATIONS: Serology (synergistic hemolysis inhibition titers > or = 512) is useful for diagnosis of internal abscesses, but not reliable for diagnosis in horses with external abscesses. Prognosis for horses with internal abscesses is considerably poorer than for those with external abscesses.
OBJECTIVE: To describe clinical manifestations of Corynebacterium pseudotuberculosis infection in horses and to evaluate diagnostic methods for identification of this disease. DESIGN: Retrospective case series. ANIMALS: 538 horses with a diagnosis of C pseudotuberculosis infection. RESULTS: Median age of horses with external abscesses was similar to that in horses with internal abscesses. Breed and sex did not appear to be associated with infection. Cases were detected during all 12 months; however, the disease was most common in the fall and early winter, with the highest incidence in September, October, and November in every year. Most horses (492/538, 91.4%) had a single episode of infection, without recurrence in subsequent years. Of 538 horses, 308 had pectoral abscesses, although infection was documented in many other anatomic locations. Forty-two horses had internal abscesses involving the abdomen or thoracic cavity. Corynebacterium pseudotuberculosis infection was readily identified by bacterial culture of aspirate samples from abscesses. The synergistic hemolysis inhibition test was useful for diagnosis of internal abscesses; however, it was unreliable for the diagnosis of external abscesses. Horses with external abscesses responded well to conventional treatment, in contrast to those with internal abscesses. The overall case fatality was low (3.9%), and was considerably lower for horses with external abscesses (0.8%) than for horses with internal abscesses (40.5%). CLINICAL IMPLICATIONS: Serology (synergistic hemolysis inhibition titers > or = 512) is useful for diagnosis of internal abscesses, but not reliable for diagnosis in horses with external abscesses. Prognosis for horses with internal abscesses is considerably poorer than for those with external abscesses.
Authors: Siomar C Soares; Artur Silva; Eva Trost; Jochen Blom; Rommel Ramos; Adriana Carneiro; Amjad Ali; Anderson R Santos; Anne C Pinto; Carlos Diniz; Eudes G V Barbosa; Fernanda A Dorella; Flávia Aburjaile; Flávia S Rocha; Karina K F Nascimento; Luís C Guimarães; Sintia Almeida; Syed S Hassan; Syeda M Bakhtiar; Ulisses P Pereira; Vinicius A C Abreu; Maria P C Schneider; Anderson Miyoshi; Andreas Tauch; Vasco Azevedo Journal: PLoS One Date: 2013-01-14 Impact factor: 3.240
Authors: Syed Shah Hassan; Luis Carlos Guimarães; Ulisses de Pádua Pereira; Arshad Islam; Amjad Ali; Syeda Marriam Bakhtiar; Dayana Ribeiro; Anderson Rodrigues Dos Santos; Siomar de Castro Soares; Fernanda Dorella; Anne Cybelle Pinto; Maria Paula Cruz Schneider; Maria Silvanira Barbosa; Síntia Almeida; Vinícius Abreu; Flávia Aburjaile; Adriana Ribeiro Carneiro; Louise Teixeira Cerdeira; Karina Fiaux; Eudes Barbosa; Carlos Diniz; Flavia S Rocha; Rommel Thiago Jucá Ramos; Neha Jain; Sandeep Tiwari; Debmalya Barh; Anderson Miyoshi; Borna Müller; Artur Silva; Vasco Azevedo Journal: Stand Genomic Sci Date: 2012-12-15