M Almagor1, C Bejar, I Kafka, H Yaffe. 1. Department of Obstetrics and Gynecology, Bikur Cholim Hospital, Jerusalem, Israel.
Abstract
OBJECTIVE: To evaluate the effect of communal growth of preimplantation human embryos on pregnancy rates in IVF-ET. DESIGN: Prospective randomized study. SETTING: In Vitro Fertilization Unit, Bikur Cholim Hospital, Jerusalem, Israel. PATIENTS: Ninety-one women undergoing 91 cycles of IVF-ET. INTERVENTION: In 42 cycles (control) embryos were grown singly, in 49 cycles (study) embryos were grown in groups until transfer. MAIN OUTCOME MEASURES: Proportion of women achieving pregnancy in study and control groups. RESULTS: Communal growth of embryos resulted in significantly improved pregnancy rates. Intrauterine transfer of embryos grown in groups produced 43% pregnancy rates per transfer, whereas, with embryos grown individually, 24% pregnancy rates were obtained (odds ratio = 2.4). CONCLUSIONS: Our study suggests that, in IVF, the potential of preimplantation human embryos to produce pregnancy tends to increase when embryos are grown in groups.
RCT Entities:
OBJECTIVE: To evaluate the effect of communal growth of preimplantation human embryos on pregnancy rates in IVF-ET. DESIGN: Prospective randomized study. SETTING: In Vitro Fertilization Unit, Bikur Cholim Hospital, Jerusalem, Israel. PATIENTS: Ninety-one women undergoing 91 cycles of IVF-ET. INTERVENTION: In 42 cycles (control) embryos were grown singly, in 49 cycles (study) embryos were grown in groups until transfer. MAIN OUTCOME MEASURES: Proportion of women achieving pregnancy in study and control groups. RESULTS: Communal growth of embryos resulted in significantly improved pregnancy rates. Intrauterine transfer of embryos grown in groups produced 43% pregnancy rates per transfer, whereas, with embryos grown individually, 24% pregnancy rates were obtained (odds ratio = 2.4). CONCLUSIONS: Our study suggests that, in IVF, the potential of preimplantation human embryos to produce pregnancy tends to increase when embryos are grown in groups.
Authors: Haley N Glatthorn; Brent M Hanson; Julia G Kim; Nola S Herlihy; Amber M Klimczak; Kathleen H Hong; Emre Seli; Richard T Scott Journal: J Assist Reprod Genet Date: 2021-06-04 Impact factor: 3.357
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