Literature DB >> 8751090

RU 24969-induced locomotion in rats is mediated by 5-HT1A receptors.

H O Kalkman1.   

Abstract

The locomotor response to RU 24969 (5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl) 1H-indole; 10 mg/kg, s.c.), a preferential 5-HT(1B) receptor agonist, was investigated in the rat, using two novel 5-HT(1A) receptor antagonists, WAY-100635 (0.3 mg/kg and 1 mg/kg, s.c.) and SDZ 216-525 (0.3 mg/kg, s.c.), and the novel 5-HT(1B)/5-HT(1D) receptor antagonist, GR 127935 (1 mg/kg, s.c.). The antagonists per se did not alter spontaneous locomotion. Both selective 5-HT(1A) receptor antagonists blocked RU 24969-induced hyperlocomotion, whilst the 5-HT(1B) receptor antagonist was without effect. These results suggest that RU 24969-induced hyperlocomotion in the rat is mediated by 5-HT(1A) receptors.

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Year:  1995        PMID： 8751090     DOI： 10.1007/bf00169395

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  7 in total

1.  Evidence that hypophagia induced by mCPP and TFMPP requires 5-HT1C and 5-HT1B receptors; hypophagia induced by RU 24969 only requires 5-HT1B receptors.

Authors:  G A Kennett; G Curzon
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530

2.  Pharmacological analysis of the behavioural and thermoregulatory effects of the putative 5-HT1 receptor agonist, RU 24969, in the rat.

Authors:  M D Tricklebank; D N Middlemiss; J Neill
Journal:  Neuropharmacology       Date:  1986-08       Impact factor: 5.250

Review 3.  Functional correlates of serotonin 5-HT1 recognition sites.

Authors:  D Hoyer
Journal:  J Recept Res       Date:  1988

Review 4.  Neuropharmacology of 5-hydroxytryptamine1B/D receptor ligands.

Authors:  P Chopin; C Moret; M Briley
Journal:  Pharmacol Ther       Date:  1994       Impact factor: 12.310

5.  Stimulation of central 5-HT1D receptors causes hypothermia in the guinea-pig.

Authors:  M Skingle; G A Higgins; W Feniuk
Journal:  J Psychopharmacol       Date:  1994-01       Impact factor: 4.153

6.  Evidence that RU 24969-induced locomotor activity in C57/B1/6 mice is specifically mediated by the 5-HT1B receptor.

Authors:  S C Cheetham; D J Heal
Journal:  Br J Pharmacol       Date:  1993-12       Impact factor: 8.739

7.  SDZ 216-525, a selective and potent 5-HT1A receptor antagonist.

Authors:  P Schoeffter; J R Fozard; A Stoll; H Siegl; M P Seiler; D Hoyer
Journal:  Eur J Pharmacol       Date:  1993-02-15       Impact factor: 4.432
  7 in total
  3 in total

1.  Comment on: Chlorpheniramine exerts anxiolytic-like effects and activates prefrontal 5-HT systems in mice (Miyata S. et al., Psychopharmacology, 2009).

Authors:  Petros N Karamanakos
Journal:  Psychopharmacology (Berl)       Date:  2010-01-19       Impact factor: 4.530

2.  MDMA self-administration fails to alter the behavioral response to 5-HT(1A) and 5-HT(1B) agonists.

Authors:  Dane Aronsen; Susan Schenk
Journal:  Psychopharmacology (Berl)       Date:  2016-02-09       Impact factor: 4.530

Review 3.  Dopamine D3 and 5-HT1B receptor dysregulation as a result of psychostimulant intake and forced abstinence: Implications for medications development.

Authors:  Janet L Neisewander; Timothy H C Cheung; Nathan S Pentkowski
Journal:  Neuropharmacology       Date:  2013-08-23       Impact factor: 5.250
  3 in total

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