Literature DB >> 87489

Different D end-dependent antigenic determinants are recognized by H-2-restricted cytotoxic T cells specific for influenza and Bebaru viruses.

R V Blanden, A Müllbacher, R B Ashman.   

Abstract

Two different BALB/c anti-CBA (H-2k)monoclonal antibodies that bind to Kk and Dk antigens blocked Tc cell-mediated lysis of L929 (Kk, Dk) target cells, but with quite different specificity. One antibody (30R3) powerfully blocked Kk-specific lysis mediated by alloreactive or Kk-restricted Tc cells immune to ectromelia, Sendai, or influenza viruses. The other antibody (27R9) blocked these anti-Kk Tc cells much less than 30R3, but in contrast, 27R9 blocked anti-Dk lysis much more than 30R3. Most importantly, 27R9 strongly blocked Dk-restricted anti-influenza Tc cells, but did not significantly block Dk-restricted anti-Bebaru (BEB) lysis. This result indicated that different H-2 determinants coded in the D end of H-2k were recognized by influenza-and BEB-immune Tc cells. These determinants may be carried on two different molecules coded by the H-2D and H-2L loci, but other possibilities are not yet excluded.

Entities:  

Mesh：

Substances：

Year:  1979        PMID： 87489      PMCID： PMC2185601          DOI： 10.1084/jem.150.1.166

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  20 in total

1.  Inhibition of cell-mediated cytolysis of trinitrophenyl-derivatized target cells by alloantisera directed to the products of the K and D loci of the H-2 complex.

Authors:  S J Burakoff; R N Germain; M E Dorf; B Benacerrah
Journal:  Proc Natl Acad Sci U S A       Date:  1976-02       Impact factor: 11.205

2.  Genes required for cytotoxicity against virus-infected target cells in K and D regions of H-2 complex.

Authors:  R V Blanden; P C Doherty; M B Dunlop; I D Gardner; R M Zinkernagel; C S David
Journal:  Nature       Date:  1975-03-20       Impact factor: 49.962

3.  Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice.

Authors:  H von Boehmer; W Haas; N K Jerne
Journal:  Proc Natl Acad Sci U S A       Date:  1978-05       Impact factor: 11.205

4.  Specificity of virus-immune effector T cells for H-2K or H-2D compatible interactions: implications for H-antigen diversity.

Authors:  P C Doherty; R V Blanden; R M Zinkernagel
Journal:  Transplant Rev       Date:  1976

5.  Ir-genes in H-2 regulate generation of anti-viral cytotoxic T cells. Mapping to K or D and dominance of unresponsiveness.

Authors:  R M Zinkernagel; A Althage; S Cooper; G Kreeb; P A Klein; B Sefton; L Flaherty; J Stimpfling; D Shreffler; J Klein
Journal:  J Exp Med       Date:  1978-08-01       Impact factor: 14.307

6.  Immunologic recognition of influenza virus-infected cells. II. Expression of influenza A matrix protein on the infected cell surface and its role in recognition by cross-reactive cytotoxic T cells.

Authors:  T J Braciale
Journal:  J Exp Med       Date:  1977-09-01       Impact factor: 14.307

7.  H-2 compatibility requirement for virus-specific T-cell-mediated cytolysis. The H-2K structure involved is coded by a single cistron defined by H-2Kb mutant mice.

Authors:  R M Zinkernagel
Journal:  J Exp Med       Date:  1976-02-01       Impact factor: 14.307

8.  Cytotoxic T-cell responses in mice infected with influenza and vaccinia viruses vary in magnitude with H-2 genotype.

Authors:  P C Doherty; W E Biddison; J R Bennink; B B Knowles
Journal:  J Exp Med       Date:  1978-08-01       Impact factor: 14.307

9.  Cell-mediated lympholysis of trinitrophenyl-modified autologous lymphocytes. Confirmation of genetic control of response to trinitrophenyl-modified H-2 antigens by the use of anti-H-2 and anti-Ia antibodies.

Authors:  A M Schmitt-Verhulst; D H Sachs; G M Shearer
Journal:  J Exp Med       Date:  1976-01-01       Impact factor: 14.307

10.  A single genetic element in H-2K affects mouse T-cell antiviral function in poxvirus infection.

Authors:  U Kees; R V Blanden
Journal:  J Exp Med       Date:  1976-02-01       Impact factor: 14.307
View more
  7 in total

1.  H-2 expression by lymphoid cells of different mouse strains: quantitative interaction of H-2 with monoclonal antibodies and their Fab fragments.

Authors:  C J Hackett; B A Askonas
Journal:  Immunology       Date:  1981-02       Impact factor: 7.397

2.  Cytotoxic T-cell recognition of influenza-infected target cells varies in different H-2k mouse strains.

Authors:  M Stringfellow; D C Wraith; B A Askonas
Journal:  Immunogenetics       Date:  1983       Impact factor: 2.846

3.  Target-cell recognition by cloned lines of influenza virus-specific cytotoxic T lymphocytes. Selective inhibition by a monoclonal H-2-specific antibody.

Authors:  T J Braciale; C F Mojcik; V Hauptfeld
Journal:  Immunogenetics       Date:  1982-01       Impact factor: 2.846

4.  Functional heterogeneity of H-2Dk-region products.

Authors:  P Démant; D Iványi; K Fischer-Lindahl
Journal:  Immunogenetics       Date:  1981       Impact factor: 2.846

5.  Influenza type A virus M protein expression on infected cells is responsible for cross-reactive recognition by cytotoxic thymus-derived lymphocytes.

Authors:  C S Reiss; J L Schulman
Journal:  Infect Immun       Date:  1980-08       Impact factor: 3.441

6.  Analysis of H-2 determinants recognized during the induction of H-Y-immune cytotoxic T cells by monoclonal antibodies in vitro.

Authors:  M Brenan; A Müllbacher
Journal:  J Exp Med       Date:  1981-08-01       Impact factor: 14.307

7.  H-2L-restricted recognition of viral antigens In the H-2d haplotype, anti-vesicular stomatitis virus cytotoxic T cells are restricted solely by H-2L.

Authors:  R Ciavarra; J Forman
Journal:  J Exp Med       Date:  1982-09-01       Impact factor: 14.307
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.