S D Boden1, D R Sumner. 1. Department of Orthopaedic Surgery, Emory University School of Medicine, Atlanta, Georgia, USA.
Abstract
STUDY DESIGN: Literature review. OBJECTIVES: This article reviews the existing data on the multiplicity of local and systemic factors affecting lumbar spinal fusion and the general biology of bone regeneration. SUMMARY OF BACKGROUND DATA: Arthrodesis is one of the most commonly performed, yet incompletely understood, procedures in spinal surgery. There exists a paucity of knowledge about the basic biology involved in achieving a successful fusion. METHODS: Medline and manual search of all relevant articles were performed and summarized. RESULTS: The success or failure of spinal fusion may be influenced by a host of local and systemic factors. CONCLUSIONS: Future research should focus on expanding our existing knowledge pertaining to the basic biology of bone regeneration specific to spinal fusion.
STUDY DESIGN: Literature review. OBJECTIVES: This article reviews the existing data on the multiplicity of local and systemic factors affecting lumbar spinal fusion and the general biology of bone regeneration. SUMMARY OF BACKGROUND DATA: Arthrodesis is one of the most commonly performed, yet incompletely understood, procedures in spinal surgery. There exists a paucity of knowledge about the basic biology involved in achieving a successful fusion. METHODS: Medline and manual search of all relevant articles were performed and summarized. RESULTS: The success or failure of spinal fusion may be influenced by a host of local and systemic factors. CONCLUSIONS: Future research should focus on expanding our existing knowledge pertaining to the basic biology of bone regeneration specific to spinal fusion.
Authors: Jason David Eubanks; Steven W Thorpe; Vinay K Cheruvu; Brett A Braly; James D Kang Journal: Clin Orthop Relat Res Date: 2011-03 Impact factor: 4.176
Authors: Alexander R Vaccaro; Tushar Patel; Jeffrey Fischgrund; D Greg Anderson; Eeric Truumees; Harry Herkowitz; Frank Phillips; Alan Hilibrand; Todd J Albert Journal: Eur Spine J Date: 2005-01-26 Impact factor: 3.134
Authors: Alexander R Vaccaro; Tushar Patel; Jeffrey Fischgrund; D Greg Anderson; Eeric Truumees; Harry Herkowitz; Frank Phillips; Alan Hilibrand; Todd J Albert Journal: Eur Spine J Date: 2003-08-08 Impact factor: 3.134