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Literature DB >> 874516

Epileptiform syndrome in rats produced by injecting tetanus toxin into the hippocampus.

J Mellanby, G George, A Robinson, P Thompson.

Abstract

An epileptiform syndrome in rats produced by injecting small doses (a few (mouse)LD50) of tetanus toxin into the hippocampus is described. The animals had intermittent seizures, with at least a superficial resemblance to human epilepsy, for some weeks but they eventually recovered. They were hyperkinetic for several weeks after the injection of toxin, and showed intermittent aggressive behaviour. Control animals which received similar injections of tetanus toxin first neutralised with antitoxin did not have seizures, and their behaviour appeared normal. EEG recordings showed characteristic seizure activity. Histological examination of the site of injection showed very little morphological damage.

Entities: Disease Species

Mesh：

Substances：
Tetanus Toxin

Year: 1977 PMID： 874516 PMCID： PMC492709 DOI： 10.1136/jnnp.40.4.404

Source DB: PubMed Journal: J Neurol Neurosurg Psychiatry ISSN： 0022-3050 Impact factor: 10.154

23 in total

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Journal: Physiol Rev Date: 1964-10 Impact factor: 37.312

2. Chronic effect of tetanus toxin applied locally to the cerebral cortex of the dog.

Authors: R CARREA; A LANARI
Journal: Science Date: 1962-08-03 Impact factor: 47.728

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Authors: J D GREEN; C E CLEMENTE; J DE GROOT
Journal: AMA Arch Neurol Psychiatry Date: 1957-09

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Authors: D WILLIAMS
Journal: Brain Date: 1953-03 Impact factor: 13.501

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Journal: J Physiol Date: 1948-01-01 Impact factor: 5.182

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Authors: J Mellanby; P A Thompson
Journal: J Physiol Date: 1972-07 Impact factor: 5.182

7. The effects of tetanus toxin on neuromuscular transmission and on the morphology of motor end-plates in slow and fast skeletal muscle of the mouse.

Authors: L W Duchen; D A Tonge
Journal: J Physiol Date: 1973-01 Impact factor: 5.182

Review 8. The thalamus and epilepsy.

Authors: D Williams
Journal: Brain Date: 1965-09 Impact factor: 13.501

9. The effect of tetanus toxin in the goldfish.

Authors: J Diamond; J Mellanby
Journal: J Physiol Date: 1971-07 Impact factor: 5.182

10. Action of tetanus toxin in the cerebral cortex.

Authors: V B BROOKS; H ASANUMA
Journal: Science Date: 1962-08-31 Impact factor: 47.728

24 in total

Review 1. Electrical stimulation for epilepsy: experimental approaches.

Authors: John D Rolston; Sharanya Arcot Desai; Nealen G Laxpati; Robert E Gross
Journal: Neurosurg Clin N Am Date: 2011-10 Impact factor: 2.509

2. Differential and time-dependent changes in gene expression for type II calcium/calmodulin-dependent protein kinase, 67 kDa glutamic acid decarboxylase, and glutamate receptor subunits in tetanus toxin-induced focal epilepsy.

Authors: F Liang; E G Jones
Journal: J Neurosci Date: 1997-03-15 Impact factor: 6.167

3. A comparison of the efficacy of carbamazepine and the novel anti-epileptic drug levetiracetam in the tetanus toxin model of focal complex partial epilepsy.

Authors: H C Doheny; M A Whittington; J G R Jefferys; P N Patsalos
Journal: Br J Pharmacol Date: 2002-03 Impact factor: 8.739

Review 4. Chronic focal epilepsy induced by intracerebral tetanus toxin.

Authors: J G Jefferys; C Borck; J Mellanby
Journal: Ital J Neurol Sci Date: 1995 Feb-Mar

5. Loss of hilar somatostatin neurons following tetanus toxin-induced seizures.

Authors: J Mitchell; M Gatherer; L E Sundstrom
Journal: Acta Neuropathol Date: 1995 Impact factor: 17.088

6. Epileptic activity outlasts disinhibition after intrahippocampal tetanus toxin in the rat.

Authors: M A Whittington; J G Jefferys
Journal: J Physiol Date: 1994-12-15 Impact factor: 5.182

7. Increased seizure susceptibility and up-regulation of nNOS expression in hippocampus following recurrent early-life seizures in rats.

Authors: Doo-Kwun Kim
Journal: J Korean Med Sci Date: 2010-05-25 Impact factor: 2.153