Literature DB >> 6873250

Different neuropathological effects of intrahippocampal injections of kainic acid and tetanus toxin.

J Kessler, H J Markowitsch.   

Abstract

Behavioral and neuroanatomical effects of hippocampal injections of kainic acid (KA) and tetanus toxin (TT) were investigated in rats. Injections of KA resulted in both local and distant neuroanatomical damage, but not in clear signs of epilepsy; injections of TT on the other hand were followed (in some of the rats) by prolonged seizure attacks, but not by neuronal damage. Based on these results it is suggested that the widespread neuronal damage following KA lesions cannot be primarily attributed to orthodromic activation of epileptic discharges. Instead, specific properties of KA and their interactions with certain transmitters may provoke widespread neuroanatomical damage.

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Year:  1983        PMID： 6873250     DOI： 10.1007/bf01990440

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  14 in total

1.  Epileptiform syndrome in rats produced by injecting tetanus toxin into the hippocampus.

Authors:  J Mellanby; G George; A Robinson; P Thompson
Journal:  J Neurol Neurosurg Psychiatry       Date:  1977-04       Impact factor: 10.154

2.  Kainic acid neurotoxicity toward hippocampal formation: dependence on specific excitatory pathways.

Authors:  J V Nadler; G J Cuthbertson
Journal:  Brain Res       Date:  1980-08-11       Impact factor: 3.252

3.  The number of hippocampal neurons in rats after electrically-induced generalized seizures.

Authors:  A M Dam; M Hertz; T G Bolwig
Journal:  Brain Res       Date:  1980-07-07       Impact factor: 3.252

4.  Electrographic, clinical and pathological alterations following systemic administration of kainic acid, bicuculline or pentetrazole: metabolic mapping using the deoxyglucose method with special reference to the pathology of epilepsy.

Authors:  Y Ben-Ari; E Tremblay; D Riche; G Ghilini; R Naquet
Journal:  Neuroscience       Date:  1981       Impact factor: 3.590

5.  Widespread patterns of neuronal damage following systemic or intracerebral injections of kainic acid: a histological study.

Authors:  J E Schwob; T Fuller; J L Price; J W Olney
Journal:  Neuroscience       Date:  1980       Impact factor: 3.590

6.  Kainic acid neurotoxicity and seizures.

Authors:  R Zaczek; M Nelson; J T Coyle
Journal:  Neuropharmacology       Date:  1981-02       Impact factor: 5.250

7.  Epidural kainate, but not ibotenate, produces lesions in local and distant regions of the brain. A comparison of the intracerebral actions of kainic acid and ibotenic acid.

Authors:  W O Guldin; H J Markowitsch
Journal:  J Neurosci Methods       Date:  1982-01       Impact factor: 2.390

8.  Behavioral and anatomical consequences of small intrastriatal injections of kainic acid in the rat.

Authors:  I Divac; H J Markowitsch; M Pritzel
Journal:  Brain Res       Date:  1978-08-11       Impact factor: 3.252

9.  Local and distant neuronal degeneration following intrastriatal injection of kainic acid.

Authors:  R Zaczek; S Simonton; J T Coyle
Journal:  J Neuropathol Exp Neurol       Date:  1980-05       Impact factor: 3.685

10.  No detectable remote lesions following massive intrastriatal injections of ibotenic acid.

Authors:  W O Guldin; H J Markowitsch
Journal:  Brain Res       Date:  1981-11-30       Impact factor: 3.252
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  3 in total

1.  Differential and time-dependent changes in gene expression for type II calcium/calmodulin-dependent protein kinase, 67 kDa glutamic acid decarboxylase, and glutamate receptor subunits in tetanus toxin-induced focal epilepsy.

Authors:  F Liang; E G Jones
Journal:  J Neurosci       Date:  1997-03-15       Impact factor: 6.167

2.  Loss of hilar somatostatin neurons following tetanus toxin-induced seizures.

Authors:  J Mitchell; M Gatherer; L E Sundstrom
Journal:  Acta Neuropathol       Date:  1995       Impact factor: 17.088

3.  Immediate Epileptogenesis after Kainate-Induced Status Epilepticus in C57BL/6J Mice: Evidence from Long Term Continuous Video-EEG Telemetry.

Authors:  Sreekanth Puttachary; Shaunik Sharma; Karen Tse; Edward Beamer; Abby Sexton; Joseph Crutison; Thimmasettappa Thippeswamy
Journal:  PLoS One       Date:  2015-07-10       Impact factor: 3.240
  3 in total

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