Literature DB >> 8742312

Is ingested inorganic arsenic a "threshold" carcinogen?

C O Abernathy1, W R Chappell, M E Meek, H Gibb, H R Guo.   

Abstract

Ingested inorganic arsenic (As) is known to be a human carcinogen. An intriguing question is whether there is a threshold for the carcinogenic effects of As, i.e., is there a level below which it does not induce the development of cancer(s)? This Roundtable will discuss the United States Environmental Protection Agency's As risk assessment using the Taiwan data from different viewpoints. It will also consider the hypothesis that there is a threshold for As and data for or against this hypothesis. For example, some scientists believe that epidemiological data cannot answer this question, while others feel that different study designs and larger sampling will provide adequate data. Reasons for each position are given. This Roundtable discussion demonstrates the controversy surrounding the use of the Taiwan data for risk assessment.

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Year:  1996        PMID: 8742312     DOI: 10.1006/faat.1996.0018

Source DB:  PubMed          Journal:  Fundam Appl Toxicol        ISSN: 0272-0590


  4 in total

Review 1.  A Systematic Review and Meta-Regression Analysis of Lung Cancer Risk and Inorganic Arsenic in Drinking Water.

Authors:  Steven H Lamm; Hamid Ferdosi; Elisabeth K Dissen; Ji Li; Jaeil Ahn
Journal:  Int J Environ Res Public Health       Date:  2015-12-07       Impact factor: 3.390

2.  Lung Cancer Risk and Low (≤50 μg/L) Drinking Water Arsenic Levels for US Counties (2009⁻2013)-A Negative Association.

Authors:  Steven H Lamm; Isabella J Boroje; Hamid Ferdosi; Jaeil Ahn
Journal:  Int J Environ Res Public Health       Date:  2018-06-07       Impact factor: 3.390

3.  Low-dose dose-response for reduced cell viability after exposure of human keratinocyte (HEK001) cells to arsenite.

Authors:  Kenneth T Bogen; Lora L Arnold; Aparajita Chowdhury; Karen L Pennington; Samuel M Cohen
Journal:  Toxicol Rep       Date:  2016-12-14

4.  Arsenic in drinking-water and risk for cancer in Denmark.

Authors:  Rikke Baastrup; Mette Sørensen; Thomas Balstrøm; Kirsten Frederiksen; Carsten Langtofte Larsen; Anne Tjønneland; Kim Overvad; Ole Raaschou-Nielsen
Journal:  Environ Health Perspect       Date:  2008-02       Impact factor: 9.031

  4 in total

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