Literature DB >> 8732770

Crystals of the neurotrophins.

R C Robinson1, C Radziejewski, D I Stuart, E Y Jones.   

Abstract

The neurotrophins show a high degree of amino acid sequence homology, share similar solution properties, and display distinct but parallel functionalities. Here we report the crystallization and preliminary X-ray characterization of three neurotrophins: brain-derived neurotrophin, neurotrophin 3, and the heterodimer between brain-derived neurotrophin and neurotrophin 4. These findings are related to other published crystal parameters for neurotrophins, leading to the observation that, although crystal packing is highly variant, neurotrophins share common solubilities with respect to crystal growth.

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Year:  1996        PMID： 8732770      PMCID： PMC2143417          DOI： 10.1002/pro.5560050520

Source DB:  PubMed          Journal:  Protein Sci        ISSN： 0961-8368            Impact factor:   6.725


  16 in total

Review 1.  Neurotrophic factors: from structure-function studies to designing effective therapeutics.

Authors:  C F Ibáñez
Journal:  Trends Biotechnol       Date:  1995-06       Impact factor: 19.536

2.  Dimeric structure and conformational stability of brain-derived neurotrophic factor and neurotrophin-3.

Authors:  C Radziejewski; R C Robinson; P S DiStefano; J W Taylor
Journal:  Biochemistry       Date:  1992-05-12       Impact factor: 3.162

3.  Neurotrophin-6 is a new member of the nerve growth factor family.

Authors:  R Götz; R Köster; C Winkler; F Raulf; F Lottspeich; M Schartl; H Thoenen
Journal:  Nature       Date:  1994-11-17       Impact factor: 49.962

4.  Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer.

Authors:  R C Robinson; C Radziejewski; D I Stuart; E Y Jones
Journal:  Biochemistry       Date:  1995-04-04       Impact factor: 3.162

5.  Characterization and crystallization of recombinant human neurotrophin-4.

Authors:  J P Fandl; N J Tobkes; N Q McDonald; W A Hendrickson; T E Ryan; S Nigam; A Acheson; H Cudny; N Panayotatos
Journal:  J Biol Chem       Date:  1994-01-07       Impact factor: 5.157

6.  New protein fold revealed by a 2.3-A resolution crystal structure of nerve growth factor.

Authors:  N Q McDonald; R Lapatto; J Murray-Rust; J Gunning; A Wlodawer; T L Blundell
Journal:  Nature       Date:  1991-12-05       Impact factor: 49.962

7.  Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.

Authors:  N Y Ip; C F Ibáñez; S H Nye; J McClain; P F Jones; D R Gies; L Belluscio; M M Le Beau; R Espinosa; S P Squinto
Journal:  Proc Natl Acad Sci U S A       Date:  1992-04-01       Impact factor: 11.205

8.  Crystallization and preliminary structural studies of neurotrophin-3.

Authors:  J A Kelly; E Singer; T D Osslund; T O Yeates
Journal:  Protein Sci       Date:  1994-06       Impact factor: 6.725

9.  Heterodimers of the neurotrophic factors: formation, isolation, and differential stability.

Authors:  C Radziejewski; R C Robinson
Journal:  Biochemistry       Date:  1993-12-07       Impact factor: 3.162

10.  Comparison of the biophysical characteristics of human brain-derived neurotrophic factor, neurotrophin-3, and nerve growth factor.

Authors:  L O Narhi; R Rosenfeld; J Talvenheimo; S J Prestrelski; T Arakawa; J W Lary; C G Kolvenbach; R Hecht; T Boone; J A Miller
Journal:  J Biol Chem       Date:  1993-06-25       Impact factor: 5.157
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