Literature DB >> 8731965

The influence of thymectomy on germ-cells of the testis in mice.

J Zeng1, Y S Zhang, S Pomer, G Staehler, D H Ren.   

Abstract

We performed thymectomy on the immature and mature male mice and made a quantitative assay of various germ cells of the seminiferous epithelium in the testis with Image Analyser System 35 days following thymectomy. The results indicated that as compared with the control group, all germ cells of the spermatogenesis lineage decreased in the immature group and in the mature group after thymectomy. The present study showed that thymus and its hormone stimulated not only the mitotic division, but also the meiotic division of germ cells during spermatogenesis, suggesting that thymus-sexual axis may play an important role in the process of spermatogenesis in the testis.

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Year:  1995        PMID： 8731965     DOI： 10.1007/BF02887914

Source DB:  PubMed          Journal:  J Tongji Med Univ        ISSN： 0257-716X


  10 in total

Review 1.  Thymic regulation of the hypothalamic-pituitary-gonadal axis.

Authors:  N R Hall; M P O'Grady; R A Menzies
Journal:  Int J Immunopharmacol       Date:  1992-04

2.  Interactions between the gonadal steroids and the immune system.

Authors:  C J Grossman
Journal:  Science       Date:  1985-01-18       Impact factor: 47.728

3.  Thymosin alpha 1 levels in human seminal plasma and follicular fluid: implication in germ cell function.

Authors:  R K Naz; P H Naylor; A L Goldstein
Journal:  Int J Fertil       Date:  1987 Sep-Oct

4.  [Effects of thymosin (fraction 5) on the endocrine function of the testis in mice].

Authors:  V M Chesnokova; E V Ignat'eva; L N Ivanova
Journal:  Biull Eksp Biol Med       Date:  1988-10

5.  Hormonal basis of reproductive defects in athymic mice: reduced gonadotropins and testosterone in males.

Authors:  R W Rebar; I C Morandini; J E Petze; G F Erickson
Journal:  Biol Reprod       Date:  1982-12       Impact factor: 4.285

6.  Effects of thymosin on the secretion of the sexual hormone in rats with experimental varicocele.

Authors:  J Zeng; Y S Zhang; Q Y Zhuang; S W Zhou
Journal:  J Tongji Med Univ       Date:  1993

7.  [Effect of thymosin (fraction 5) on the development of functional activity of the adrenals and gonads in genetically athymic mice].

Authors:  E V Ignat'eva; V M Chesnokova; V M Iunker; L N Ivanova; O M Tepelina
Journal:  Probl Endokrinol (Mosk)       Date:  1988 Nov-Dec

8.  Evidence for thymus involvement in development of adrenal and gonadal endocrine functions in mice.

Authors:  V M Chesnokova; E V Grutenko; L N Ivanova; E V Ignatyeva
Journal:  Endocrinol Exp       Date:  1987-06

9.  A thymus factor influences the in vitro testosterone secretion of Leydig cells in the rat.

Authors:  E Pedernera; J Díaz-Osuna; M Calcagno
Journal:  Life Sci       Date:  1986-03-03       Impact factor: 5.037

10.  Thymosin alpha-1 enhances the fertilizing capacity of human sperm cell: implication in diagnosis and treatment of male infertility.

Authors:  R K Naz; P Kaplan; A L Goldstein
Journal:  Biol Reprod       Date:  1992-12       Impact factor: 4.285
  10 in total

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