Literature DB >> 8731925

Effect of captopril on membrane currents of ventricular myocytes.

Y G Wang1, Z Y Lu.   

Abstract

Using whole-cell patch-clamp technique, the present study examined the effects of captopril on membrane currents of ventricular myocytes. The results were as follow: when the concentration of captopril was 6 x 10(-4)mol, the fast inward sodium current and slow inward calcium current were all decreased significantly (P < 0.05). Besides, when the concentration exceeds 10(-3)mol, the delayed rectifier potassium current was increased (P < 0.05) as well. But if the experimental concentration was under 6 x 10(-4)mol, these three kinds of currents was not affected. These findings suggested that captopril has no direct antiarrhythmic effect at the average therapeutic serum level.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 8731925     DOI： 10.1007/BF02887946

Source DB:  PubMed          Journal:  J Tongji Med Univ        ISSN： 0257-716X


  10 in total

1.  Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.

Authors:  O P Hamill; A Marty; E Neher; B Sakmann; F J Sigworth
Journal:  Pflugers Arch       Date:  1981-08       Impact factor: 3.657

2.  Cardiac electrophysiological actions of captopril: lack of direct antiarrhythmic effects.

Authors:  P D Hemsworth; R T Pallandi; T J Campbell
Journal:  Br J Pharmacol       Date:  1989-09       Impact factor: 8.739

3.  Captopril reduces purine loss and reperfusion arrhythmias in the rat heart after coronary artery occlusion.

Authors:  W H Van Gilst; P A De Graeff; J H Kingma; H Wesseling; C D De Langen
Journal:  Eur J Pharmacol       Date:  1984-04-13       Impact factor: 4.432

4.  Effects of captopril on membrane current and contraction in single ventricular myocytes from guinea-pig.

Authors:  S M Bryant; K O Ryder; G Hart
Journal:  Br J Pharmacol       Date:  1991-02       Impact factor: 8.739

5.  Effects of intravenous captopril on inducible sustained ventricular tachycardia one week after experimental infarction in the anaesthetized pig.

Authors:  J H Kingma; P A de Graeff; W H van Gilst; E van Binsbergen; C D de Langen; H Wesseling
Journal:  Postgrad Med J       Date:  1986       Impact factor: 2.401

6.  Effect of vasodilator drugs on coronary occlusion and reperfusion arrhythmias in anesthetized dogs.

Authors:  M S Elfellah; R I Ogilvie
Journal:  J Cardiovasc Pharmacol       Date:  1985 Sep-Oct       Impact factor: 3.105

7.  Converting enzyme inhibitors (captopril, enalapril, perindopril) prevent early-post infarction ventricular fibrillation in the anaesthetized rat.

Authors:  C Ribuot; L Rochette
Journal:  Cardiovasc Drugs Ther       Date:  1987       Impact factor: 3.727

8.  Effect of enalapril on ventricular arrhythmias in congestive heart failure.

Authors:  M W Webster; M A Fitzpatrick; M G Nicholls; H Ikram; J E Wells
Journal:  Am J Cardiol       Date:  1985-09-15       Impact factor: 2.778

9.  Effect of oral captopril on premature ventricular complexes in patients with preserved left ventricular systolic function: a randomized clinical trial.

Authors:  R T Steinman; D Gilley; S Gunther; B S Fromm; M H Lehmann
Journal:  Clin Cardiol       Date:  1993-02       Impact factor: 2.882

10.  Beneficial effects of the converting enzyme inhibitor, ramipril, in ischemic rat hearts.

Authors:  W Linz; B A Schölkens; Y F Han
Journal:  J Cardiovasc Pharmacol       Date:  1986       Impact factor: 3.105
  10 in total
  1 in total

1.  Evaluation of the rabbit Purkinje fibre assay as an in vitro tool for assessing the risk of drug-induced torsades de pointes in humans.

Authors:  Marion Aubert; Rolf Osterwalder; Björn Wagner; Isabelle Parrilla; Icilio Cavero; Lucette Doessegger; Eric A Ertel
Journal:  Drug Saf       Date:  2006       Impact factor: 5.606
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.