AIM OF THE STUDY: To determine the levels of the inflammatory cytokines IL1 alpha, IL1 beta, TNF alpha, IL6, IL8 and of their inhibitors TNF-sR55, TNF-s R75 and IL1-Ra during temperature elevation in systemic juvenile chronic arthritis. METHODS: Fifty-six serum samples were collected at regular intervals from seven children during 8 fever cycles. Cytokine levels were determined using enzyme-linked immunoassays. RESULTS: Levels of IL1 alpha, IL1 beta, TNF alpha and IL8 showed no variations. In contrast, IL6 and IL1-Ra levels paralleled the fever spikes. TNF-sR75 levels were also correlated with the fever. CONCLUSION: Fever dynamics in systemic juvenile chronic arthritis may be partly related to cytokine variations.
AIM OF THE STUDY: To determine the levels of the inflammatory cytokines IL1 alpha, IL1 beta, TNF alpha, IL6, IL8 and of their inhibitors TNF-sR55, TNF-s R75 and IL1-Ra during temperature elevation in systemic juvenile chronic arthritis. METHODS: Fifty-six serum samples were collected at regular intervals from seven children during 8 fever cycles. Cytokine levels were determined using enzyme-linked immunoassays. RESULTS: Levels of IL1 alpha, IL1 beta, TNF alpha and IL8 showed no variations. In contrast, IL6 and IL1-Ra levels paralleled the fever spikes. TNF-sR75 levels were also correlated with the fever. CONCLUSION:Fever dynamics in systemic juvenile chronic arthritis may be partly related to cytokine variations.
Authors: Hulya Bukulmez; Mark Fife; Monica Tsoras; Susan D Thompson; Natalie A Twine; Patricia Woo; Jane M Olson; Robert C Elston; David N Glass; Robert A Colbert Journal: Arthritis Res Ther Date: 2005-01-11 Impact factor: 5.156