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Literature DB >> 10649636

Analysis of cytokine dynamics in corneal allograft rejection.

Abstract

Motivated by the discovery of oscillations in tumour necrosis factor-alpha (TNF-alpha) concentration in the aqueous humour of rabbits undergoing corneal allograft rejection, a simple mathematical model is developed for the regulation of TNF-alpha, which incorporates both negative feedback and amplification pathways. Mathematical analysis reveals a surprisingly rich behavioural repertoire for this simple cytokine pathway, including excitability, threshold behaviour, hysteresis, oscillations and bistability. This suggests new possibilities for experimental demonstration, and reveals the potential contributions of nonlinear dynamics to understanding cytokine regulation.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1999 PMID： 10649636 PMCID： PMC1690347 DOI： 10.1098/rspb.1999.0911

Source DB: PubMed Journal: Proc Biol Sci ISSN： 0962-8452 Impact factor: 5.349

19 in total

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Review 2. Concise review: immunological properties of ocular surface and importance of limbal stem cells for transplantation.

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