Literature DB >> 8729769

The value of CSF analysis for the differential diagnosis of HTLV-I associated myelopathy and multiple sclerosis.

M Puccioni-Sohler1, B Kitze, K Felgenhauer, I T Graef, P Lange, S Novis, H Reiber, B Vaz.   

Abstract

Cerebrospinal fluid (CSF) and serum of 17 patients with HAM/TSP (HTLV-I associated myelopathy/tropical spastic paraparesis), six with multiple sclerosis and six with idiopathic epilepsy (non inflammatory control) from Brazil were analysed for the presence of intrathecal synthesis of virus-specific antibodies against measles, rubella, varicella zoster virus and herpes simplex virus by enzyme-linked immunosorbent assay (ELISA). All HAM/TSP and multiple sclerosis cases had an intrathecal immune response (oligoclonal IgG). In HAM/TSP, only 1/17 case showed a polyspecific intrathecal immune response against measles and rubella virus. In multiple sclerosis, specific antibodies against measles and rubella (MRZ response) were observed in all patients but not in the control with idiopathic epilepsy. The diagnostic and theoretical relevance of mono- and polyspecific immune responses is discussed for these chronic neurological diseases.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 8729769     DOI： 10.1590/s0004-282x1995000500008

Source DB:  PubMed          Journal:  Arq Neuropsiquiatr        ISSN： 0004-282X            Impact factor:   1.420


  8 in total

Review 1.  The MRZ reaction as a highly specific marker of multiple sclerosis: re-evaluation and structured review of the literature.

Authors:  S Jarius; P Eichhorn; D Franciotta; H F Petereit; G Akman-Demir; M Wick; B Wildemann
Journal:  J Neurol       Date:  2016-12-22       Impact factor: 4.849

2.  The MRZ reaction and a quantitative intrathecal IgG synthesis may be helpful to differentiate between primary central nervous system lymphoma and multiple sclerosis.

Authors:  Tilman Hottenrott; Elisabeth Schorb; Kristina Fritsch; Rick Dersch; Benjamin Berger; Daniela Huzly; Sebastian Rauer; Ludger Tebartz van Elst; Dominique Endres; Oliver Stich
Journal:  J Neurol       Date:  2018-03-06       Impact factor: 4.849

Review 3.  Low intrathecal antibody production despite high seroprevalence of Epstein-Barr virus in multiple sclerosis: a review of the literature.

Authors:  Klemens Ruprecht; Brigitte Wildemann; Sven Jarius
Journal:  J Neurol       Date:  2017-11-02       Impact factor: 4.849

4.  The intrathecal, polyspecific antiviral immune response in neurosarcoidosis, acute disseminated encephalomyelitis and autoimmune encephalitis compared to multiple sclerosis in a tertiary hospital cohort.

Authors:  Tilman Hottenrott; Rick Dersch; Benjamin Berger; Sebastian Rauer; Matthias Eckenweiler; Daniela Huzly; Oliver Stich
Journal:  Fluids Barriers CNS       Date:  2015-12-13

Review 5.  Does disease-irrelevant intrathecal synthesis in multiple sclerosis make sense in the light of tertiary lymphoid organs?

Authors:  Mickael Bonnan
Journal:  Front Neurol       Date:  2014-03-11       Impact factor: 4.003

6.  The MRZ reaction in primary progressive multiple sclerosis.

Authors:  Tilman Hottenrott; Rick Dersch; Benjamin Berger; Sebastian Rauer; Daniela Huzly; Oliver Stich
Journal:  Fluids Barriers CNS       Date:  2017-02-07

7.  Intrathecal, polyspecific antiviral immune response in oligoclonal band negative multiple sclerosis.

Authors:  Isabel Brecht; Benedikt Weissbrich; Julia Braun; Klaus Viktor Toyka; Andreas Weishaupt; Mathias Buttmann
Journal:  PLoS One       Date:  2012-07-09       Impact factor: 3.240

8.  The MRZ reaction helps to distinguish rheumatologic disorders with central nervous involvement from multiple sclerosis.

Authors:  Tilman Hottenrott; Rick Dersch; Benjamin Berger; Dominique Endres; Daniela Huzly; Jens Thiel; Sebastian Rauer; Oliver Stich; Ulrich Salzer; Nils Venhoff
Journal:  BMC Neurol       Date:  2018-01-31       Impact factor: 2.474
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.