| Literature DB >> 872628 |
J W Allen, C F Shuler, R W Mendes, S A Latt.
Abstract
A small tablet of 5-bromodeoxyuridine (BrdU), implanted subcutaneously in a mouse, provides sustained release of base analog sufficient to effect substitution of DNA throughout an entire replication period. As illustrated by studies of mouse bone-marrow and spleen cells in the presence or absence of cyclophosphamide, this depot method of BrdU administration greatly simplifies in vivo analysis of sister-chromatid-exchange formation.Entities:
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Year: 1977 PMID: 872628 DOI: 10.1159/000130765
Source DB: PubMed Journal: Cytogenet Cell Genet ISSN: 0301-0171