Literature DB >> 8725943

Immunoglobulin class switching.

J Stavnezer1.   

Abstract

Antibody class switching is induced by B-cell activators in the presence of cytokines. The identity of the heavy-chain class to which a B cell is switched is regulated by cytokines and B-cell activators at the level of transcription of unrearranged heavy chain constant genes. Gene-targeting experiments in mice have proved the essential role of these transcripts in switch recombination. Their possible functions are discussed in the context of a model for the mechanisms of class switching.

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Year:  1996        PMID： 8725943     DOI： 10.1016/s0952-7915(96)80058-6

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  78 in total

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