Literature DB >> 8725249

The probability distribution of the amount of an individual's genome surviving to the following generation.

H Bickeböller1, E A Thompson.   

Abstract

The probability that at least p% of an individual's genome is passed on collectively to his children is calculated. With data availability the consideration of the chromosome as a whole rather than discrete loci becomes of increasing practical importance. Assuming the genomic continuum model, which allows for recombination, the crossover process in a chromosome pedigree is viewed as a continuous-time Markov random walk on the vertices of a hypercube with time parameter map distance along the chromosome. The desired probability corresponds to the probability of sojourn times of the process in a small set of vertices, which are well approximated via the Poisson clumping heuristic. Results are given for the human genome. It is very likely that an individual with at least four children passes on at least 90% of his genome. There exists no "equivalent" number of independently segregating loci for this distribution.

Entities:  

Mesh:

Year:  1996        PMID: 8725249      PMCID: PMC1207322     

Source DB:  PubMed          Journal:  Genetics        ISSN: 0016-6731            Impact factor:   4.562


  4 in total

1.  Multipoint analysis of human quantitative genetic variation.

Authors:  D E Goldgar
Journal:  Am J Hum Genet       Date:  1990-12       Impact factor: 11.025

2.  Computation of identity-by-descent proportions shared by two siblings.

Authors:  S W Guo
Journal:  Am J Hum Genet       Date:  1994-06       Impact factor: 11.025

3.  The distribution of the proportion of the genome which is homozygous by descent in inbred individuals.

Authors:  I R Franklin
Journal:  Theor Popul Biol       Date:  1977-02       Impact factor: 1.570

4.  Multilocus linkage analysis in humans: detection of linkage and estimation of recombination.

Authors:  G M Lathrop; J M Lalouel; C Julier; J Ott
Journal:  Am J Hum Genet       Date:  1985-05       Impact factor: 11.025

  4 in total
  10 in total

1.  Distribution of genome shared identical by descent by two individuals in grandparent-type relationship.

Authors:  V T Stefanov
Journal:  Genetics       Date:  2000-11       Impact factor: 4.562

Review 2.  Identity by descent: variation in meiosis, across genomes, and in populations.

Authors:  Elizabeth A Thompson
Journal:  Genetics       Date:  2013-06       Impact factor: 4.562

3.  Association studies for next-generation sequencing.

Authors:  Li Luo; Eric Boerwinkle; Momiao Xiong
Journal:  Genome Res       Date:  2011-04-26       Impact factor: 9.043

4.  Distribution of parental genome blocks in recombinant inbred lines.

Authors:  Olivier C Martin; Frédéric Hospital
Journal:  Genetics       Date:  2011-08-11       Impact factor: 4.562

5.  The lengths of admixture tracts.

Authors:  Mason Liang; Rasmus Nielsen
Journal:  Genetics       Date:  2014-04-26       Impact factor: 4.562

6.  Methods for collapsing multiple rare variants in whole-genome sequence data.

Authors:  Yun Ju Sung; Keegan D Korthauer; Michael D Swartz; Corinne D Engelman
Journal:  Genet Epidemiol       Date:  2014-09       Impact factor: 2.135

7.  Variation in actual relationship as a consequence of Mendelian sampling and linkage.

Authors:  W G Hill; B S Weir
Journal:  Genet Res (Camb)       Date:  2011-02       Impact factor: 1.588

8.  Statistics on continuous IBD data: exact distribution evaluation for a pair of full(half)-sibs and a pair of a (great-) grandchild with a (great-) grandparent.

Authors:  Valeri T Stefanov
Journal:  BMC Genet       Date:  2002-05-07       Impact factor: 2.797

9.  Estimating the timing of multiple admixture events using 3-locus linkage disequilibrium.

Authors:  Mason Liang; Mikhail Shishkin; Anastasia Mikhailova; Vladimir Shchur; Rasmus Nielsen
Journal:  PLoS Genet       Date:  2022-07-15       Impact factor: 6.020

10.  A comprehensive evaluation of collapsing methods using simulated and real data: excellent annotation of functionality and large sample sizes required.

Authors:  Carmen Dering; Inke R König; Laura B Ramsey; Mary V Relling; Wenjian Yang; Andreas Ziegler
Journal:  Front Genet       Date:  2014-09-15       Impact factor: 4.599

  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.