Literature DB >> 872370

Analysis for platinum in biological material by flameless atomic absorption spectrometry.

M F Pera, H C Harder.   

Abstract

A method for determining platinum in biological materials by flameless atomic absorption spectrometry has been developed for use in pharmacological studies of platinum antitumor compounds. Tissue digests are analyzed in a heated graphite atomizer, with use of background correction and ramp temperature charring. We have overcome problems of apparent loss of platinum in Pt-supplemented tissue samples with time and of difficulty in analyzing tissue lipid. The validity of the assay was verified by injecting rats with radiolabeled cis-dichlorodiammineplatinum (II), then measuring platinum in tissues by gamma scintillation spectrometry and flameless atomic absorption spectrometry. Correlation between the two methods was excellent. The limit of the assay in its present form is about 0.1 migrogram/gram of wet tissue.

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Year:  1977        PMID： 872370

Source DB:  PubMed          Journal:  Clin Chem        ISSN： 0009-9147            Impact factor:   8.327


  15 in total

1.  Effect of hyaluronidase on the pharmacokinetics of free and total platinum species after intra-arterial Cisplatin in refractory patients with colorectal liver metastases.

Authors:  D Civalleri; M Esposito; F De Cain; F Decian; N Balletto; G Mondini; L Gogioso; M Viale; M O Vannozzi
Journal:  Clin Drug Investig       Date:  1996-08       Impact factor: 2.859

Review 2.  Platinum antitumour agents: a review of (bio)analysis.

Authors:  T J Hodes; W J Underberg; G Los; J H Beijnen
Journal:  Pharm Weekbl Sci       Date:  1992-06-19

3.  In vivo imaging with a cell-permeable porphyrin-based MRI contrast agent.

Authors:  Taekwan Lee; Xiao-an Zhang; Shanta Dhar; Henryk Faas; Stephen J Lippard; Alan Jasanoff
Journal:  Chem Biol       Date:  2010-06-25

4.  In vitro evaluation of sustained drug release from biodegradable elastomer.

Authors:  R Wada; S H Hyon; T Nakamura; Y Ikada
Journal:  Pharm Res       Date:  1991-10       Impact factor: 4.200

5.  Inactivation of cis-diamminedichloroplatinum (II) in blood and protection of its toxicity by sodium thiosulfate in rabbits.

Authors:  Y Iwamoto; T Kawano; M Ishizawa; K Aoki; T Kuroiwa; T Baba
Journal:  Cancer Chemother Pharmacol       Date:  1985       Impact factor: 3.333

6.  Disposition of total and free cisplatin on two consecutive treatment cycles in patients with ovarian cancer.

Authors:  C Erlichman; S J Soldin; J J Thiessen; J F Sturgeon; S Fine
Journal:  Cancer Chemother Pharmacol       Date:  1987       Impact factor: 3.333

7.  Energy-dispersive X-ray fluorescence determination of platinum in plasma, urine, and cerebrospinal fluid of patients administered cis-dichlorodiammineplatinum(II).

Authors:  W E Seifert; D J Stewart; R S Benjamin; R M Caprioli
Journal:  Cancer Chemother Pharmacol       Date:  1983       Impact factor: 3.333

8.  A comparative study of the distribution in the male rat of platinum-labelled cis-dichlorodiammine platinum (II), cis-trans-dichlorodihydroxy-bis-(isopropylamine) platinum (I), and cis-dichloro-bis-cyclopropylamine platinum (II).

Authors:  R Harrison; C A McAuliffe; A Zaki; J Baer; H Sharma; A Smith; H Jackson; B W Fox
Journal:  Cancer Chemother Pharmacol       Date:  1983       Impact factor: 3.333

9.  Permeability of the rat bladder to Cisplatinum under different conditions: comparison with Mitomycin C and Adriamycin.

Authors:  U Engelmann; G Oelsner; R A Bürger; H Wagner
Journal:  Urol Res       Date:  1983

10.  The effect of heavy metal chelators on the renal accumulation of platinum after cis-dichlorodiammineplatinum II administration to the rat.

Authors:  J Graziano; B Jones; P Pisciotto
Journal:  Br J Pharmacol       Date:  1981-07       Impact factor: 8.739
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